Filamentous inclusions in nonneoplastic and neoplastic pancreas: an ultrastructural and immunogold labeling study

Ultrastructural Pathology
G PasquinelliE Venza

Abstract

Filamentous inclusions (FI) are unusual, irregularly shaped cytoplasmic inclusions, which are mostly found in acinar cell carcinomas of the pancreas and are consequently thought to be an abnormal zymogen granule type. This study describes identical inclusions in acinar, centroacinar, and small duct epithelial cells from nonneoplastic pancreas, as well as those found in tumor cells from a mixed acinar-endocrine pancreatic carcinoma. An ultrastructural and immunogold labeling demonstration indicates that these inclusions are aggregates of intermediate filaments immunoreacting with the anti-cytokeratin AE1/AE3 mixture and with V9 clone anti-vimentin monoclonal antibodies. Their pleomorphic appearance, variable immunoreactivity, and frequent association with lipid droplets and secondary lysosomes, mostly of the angulate type, led to the hypothesis that the FI undergo a degenerative remodeling pathway similar to that proposed for hepatic Mallory bodies. A survey of the literature on FI and human tumors suggests that they are a variably expressed ultrastructural feature of tumor cells originating from exocrine cell-containing tissues, namely the pancreas and gastrointestinal tract.

References

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Citations

Feb 2, 2002·Experimental Hematology·Francesca ReDamiano Rondelli
Feb 18, 2010·Proceedings of the American Thoracic Society·Micah R RogelKaren M Ridge
Jan 16, 2007·World Journal of Surgery·Hiroshi KuraharaTakashi Aikou
May 23, 2008·Surgical Oncology·Sonshin TakaoHiroyuki Shinchi
May 29, 2007·Experimental Cell Research·Kurt ZatloukalM Bishr Omary
Mar 20, 2008·The American Journal of Pathology·Diana M ToivolaM Bishr Omary
Mar 9, 2012·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J KaťuchováJ Radoňak
May 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David S Klimstra

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