Filgrastim to treat neutropenia and support myelosuppressive medication dosing in HIV infection. G-CSF 92105 Study Group

AIDS
P HermansN Clumeck

Abstract

Patients with HIV infection frequently experience disease or treatment-related myelosuppression leading to neutropenia. Neutropenia often leads to dose-reduction or discontinuation of important myelosuppressive therapy. To examine the efficacy and safety of filgrastim for reversing neutropenia and determine the effect of this on use of myelosuppressive medications. Open-label, non-comparative, multicentre study in 200 HIV-positive patients with neutropenia [absolute neutrophil count (ANC) < 1.0 x 10(9)/l]. Filgrastim was started at 1 microgram/kg/day subcutaneously for 28 days. This initial treatment phase was followed by a maintenance phase, using 300 micrograms on 1-7 days/week. In both phases the dose of filgrastim was adjusted to achieve an ANC of 2-5 x 10(9)/l. Filgrastim reversed neutropenia in 98% of patients (ANC > or = 2 x 10(9)/l), with a median time to reversal of 2 days (range 1-16) and a median dose of 1 microgram/kg/day (range 0.5-10). Most patients (96%) achieved reversal of neutropenia with a filgrastim dose of < or = 300 micrograms/day (< or = 1 vial/day). Normal ANCs were then maintained with a median of 1 microgram/kg/day (range 0.22-10.6) during the treatment phase and 3 x 300 micrograms vials/week (range 1-...Continue Reading

Citations

Dec 13, 2005·Sexual Health·Anthony JaworowskiSteven L Wesselingh
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D R Kuritzkes
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A MooreB G Gazzard
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W S Armstrong, P Kazanjian
Apr 20, 2002·AIDS·Michael DavidsonUNKNOWN Studies of Ocular Complications of AIDS Research Group
Jun 13, 2001·Sexually Transmitted Infections·A J White
Oct 10, 2015·British Journal of Haematology·Prakash Vishnu, David M Aboulafia
Mar 25, 2014·International Reviews of Immunology·Xin ShiPing Zhang
Jan 7, 2017·Journal of Pediatric Hematology/oncology·Bethany A WattlesJoshua J Elder
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug

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