Filter-less submicron hydrodynamic size sorting

Lab on a Chip
M FouetP Joseph

Abstract

We propose a simple microfluidic device able to separate submicron particles (critical size ∼0.1 μm) from a complex sample with no filter (minimum channel dimension being 5 μm) by hydrodynamic filtration. A model taking into account the actual velocity profile and hydrodynamic resistances enables prediction of the chip sorting properties for any geometry. Two design families are studied to obtain (i) small sizes within minutes (low-aspect ratio, two-level chip) and (ii) micron-sized sorting with a μL flow rate (3D architecture based on lamination). We obtain quantitative agreement of sorting performances both with experiments and with numerical solving, and determine the limits of the approach. We therefore demonstrate a passive, filter-less sub-micron size sorting with a simple, robust, and easy to fabricate design.

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Citations

Apr 28, 2018·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Olivier LiotPierre Joseph
Jun 27, 2018·Lab on a Chip·Armaghan FakhfouriAdrian Neild
May 17, 2018·Journal of Lipid Research·Michel RecordMichael J O Wakelam
Sep 23, 2018·Electrophoresis·Yanli GongHai Jiang
Dec 14, 2019·APL Bioengineering·Jian ZhouIan Papautsky

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