Filter-probe diffusion imaging improves spinal cord injury outcome prediction

Annals of Neurology
Nathan P SkinnerMatthew D Budde

Abstract

Diffusion-weighted imaging (DWI) is a powerful tool for investigating spinal cord injury (SCI), but has limited specificity for axonal damage, which is the most predictive feature of long-term functional outcome. In this study, a technique designed to detect acute axonal injury, filter-probe double diffusion encoding (FP-DDE), is compared with standard DWI for predicting long-term functional and cellular outcomes. This study extends FP-DDE to predict long-term functional and histological outcomes in a rat SCI model of varying severities (n = 58). Using a 9.4T magnetic resonance imaging (MRI) system, a whole-cord FP-DDE spectroscopic voxel was acquired in 3 minutes at the lesion site and compared to DWI at 48 hours postinjury. Relationships with chronic (30-day) locomotor and histological outcomes were evaluated with linear regression. The FP-DDE measure of parallel diffusivity (ADC|| ) was significantly related to chronic hind limb locomotor functional outcome (R2  = 0.63, p < 0.0001), and combining this measurement with acute functional scores demonstrated prognostic benefit versus functional testing alone (p = 0.0007). Acute ADC|| measurements were also more closely related to the number of injured axons measured 30 days afte...Continue Reading

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Citations

Apr 6, 2019·Journal of Neurotrauma·Mayank KaushalShekar Kurpad
Dec 14, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kevin M KochMatthew D Budde
Nov 5, 2020·Journal of Neuroscience Methods·Rafael N HenriquesAndrada Ianuş
Jan 30, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Briana P MeyerMatthew D Budde
Mar 16, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Seung-Yi LeeMatthew D Budde
Jun 1, 2021·Neurosurgery Clinics of North America·Saman ShabaniMarjorie C Wang

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