Filtration coefficients and osmotic reflexion coefficients of the walls of single frog mesenteric capillaries

The Journal of Physiology
C C Michel

Abstract

1. Single capillaries in the mesentery of pithed frogs were perfused with frog Ringer solutions containing various concentrations of bovine serum albumin and myoglobin. Filtration coefficients (Lp) of the capillary wall were determined from measurements of fluid filtration rate at a series of different capillary pressures (Michel, Mason, Curry & Tooke, 1974). The osmotic reflexion coefficients (sigma) to albumin and myoglobin were determined by comparing the effective osmotic pressure exerted by these solutes across the capillary walls with their osmotic pressures in a membrane osmometer. 2. Lp and sigma to albumin were measured in eighteen vessels at different sites in the capillary bed with the tissue temperature in the range of 20-24 degrees C. Lp varied from 1.5 x 10(-3) to 15 x 10(-3) micrometer sec-1 cm H2O-1 having a higher mean value in nine venous capillaries (11.33 x 10(-3) micrometer sec-1 cm H2O-1) than in nine arterial and mid-capillaries (4.83 x 10(-3) micrometer sec-1 cm H2O-1). For all eighteen vessels sigma to albumin had a mean value of 0.816 (S.E. of mean +/- 0.027). There was no correlation between Lp and sigma. The mean value of sigma for the venous capillaries was 0.841 (S.E. of mean +/- 0.04) and the othe...Continue Reading

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