Final adult height in long-term growth hormone-treated achondroplasia patients

European Journal of Pediatrics
Daisuke HaradaY Seino

Abstract

The objective of this study was to evaluate the gain in final height of achondroplasia (ACH) patients with long-term growth hormone (GH) treatment. We analyzed medical data of 22 adult patients (8 males and 14 females) treated with GH at a dose of 0.05 mg/kg/day. Optionally, tibial lengthening (TL) was performed with the Ilizalov method in 15 patients and TL as well as femoral lengthening (FL) in 6 patients. Concomitant gonadal suppression therapy with buserelin acetate was applied in 13 patients. The mean treatment periods with GH were 10.7 ± 4.0 and 9.3 ± 2.5 years for males and females, respectively. GH treatment augmented the final height +0.60 ± 0.52 SD (+3.5 cm) and +0.51 ± 1.29 SD (+2.8 cm) in males and females compared to non-treated ACH patients, respectively. Final height of ACH patients that underwent GH and TL increased +1.72 ± 0.72 SD (+10.0 cm) and +1.95 ± 1.34 SD (+9.8 cm) in males and females, respectively. GH, TL, and FL increased their final height +2.97 SD (+17.2 cm) and +3.41 ± 1.63 SD (+17.3 cm) in males and females, respectively. Gonadal suppression therapy had no impact on final height. Long-term GH treatment contributes to 2.6 and 2.1% of final adult height in male and female ACH patients, respectively.

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Citations

Jun 8, 2018·Journal of Pediatric Orthopedics. Part B·Izumi KadonoNaoki Ishiguro
Feb 2, 2019·Calcified Tissue International·Masaki MatsushitaNaoki Ishiguro
Aug 18, 2020·American Journal of Medical Genetics. Part a·Pamela K ForemanSarah Landis
Jul 4, 2019·The New England Journal of Medicine·Ravi SavarirayanJulie Hoover-Fong
Jan 5, 2019·Orphanet Journal of Rare Diseases·Richard M Pauli
Feb 8, 2020·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Takuo KubotaKeiichi Ozono
May 18, 2020·Current Osteoporosis Reports·Holly L Racine, Maria A Serrat
Sep 8, 2020·Nursing Children and Young People·Doreen Crawford, Beth Wilson
Jan 8, 2021·Nursing Children and Young People·Doreen CrawfordKate Davies
Jun 3, 2021·International Journal of Molecular Sciences·Wiktoria WrobelIwona Ben-Skowronek
Aug 18, 2021·Disability and Rehabilitation·Constantinos ConstantinidesPenelope J Ireland
Aug 26, 2021·Clinical Pharmacokinetics·Ming Liang ChanJoshua Henshaw
Nov 12, 2021·Expert Opinion on Emerging Drugs·Smitha Kumble, Ravi Savarirayan

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