PMID: 8961126Sep 1, 1996Paper

Final height outcome in both untreated and testosterone-treated boys with constitutional delay of growth and puberty

Journal of Pediatric Endocrinology & Metabolism : JPEM
T ArrigoV De Sanctis

Abstract

The present retrospective study is based on a historical follow-up of 49 boys with constitutional delay of growth and puberty (CDGP) who went into puberty spontaneously (27 cases) or induced by depotestosterone treatment, 50 mg/ month for 6 months (22 cases). At the time of puberty the two groups of boys were similar in bone age, height deficiency, target height (TH) and had similar predicted final heights (FH). Their FH was measured and compared with TH calculated from measured parents' heights. FH did not significantly differ between the untreated boys and those treated. In the two groups of patients FH was similar and corresponded to both TH and height predicted at puberty onset. This study confirms that most boys with CDGP spontaneously attain a FH within the target range (24/27 cases). A short-term and low dose course of depotestosterone can be used without adverse effects on FH. The Bayley-Pinneau method can be generally considered accurate for predicting FH in CDGP, although significant discrepancies between FH and predicted height have been recorded in a fair number of both untreated and treated boys.

References

Jan 1, 1991·Hormone Research·G von KalckreuthR H Rosskamp
Oct 1, 1990·Archives of Disease in Childhood·E C CrowneD A Price
Dec 1, 1970·Archives of Disease in Childhood·J M TannerR H Whitehouse
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Citations

Apr 24, 2013·Nature Reviews. Endocrinology·Michael B Ranke
Aug 25, 2007·European Journal of Pediatrics·Stefano ZucchiniStefano Cianfarani
Jul 15, 2005·Expert Opinion on Pharmacotherapy·Alan D Rogol
Mar 9, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sükran PoyrazoğluFirdevs Baş
May 21, 2010·Expert Opinion on Pharmacotherapy·Anthony Yin, Ronald Swerdloff
Aug 16, 2003·Clinical Endocrinology·Alberto Scofano Mainieri, Regina Helena Elnecave
Dec 10, 2020·Journal of the Endocrine Society·Maria VogiatziAlan D Rogol
May 3, 2019·Hormone Research in Pædiatrics·Thomas ReinehrGerhard Binder

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