Final height outcome in girls with Turner syndrome treated with a combination of low dose oestrogen and oxandrolone

European Journal of Pediatrics
P BareilleR Stanhope

Abstract

Final stature in girls with Turner syndrome treated with combination of low dose oestrogen and oxandrolone. Nineteen prepubertal girls with Turner syndrome (mean age 10.9 years, range, 8.9-14.2 years) were randomly assigned to receive either oxandrolone (0.05 mg/kg/day) or ethinyloestradiol (40 ng/kg/day) for 1 year. Subsequently the alternate therapy was added and the combination given until attainment of final height. Ethinyloestradiol was gradually increased at the age of 12.5 years in order to induce secondary sexual characteristics. The duration of treatment was a mean of 5.2 years (range, 3.7 years) when the 1st year of monotherapy was included. Therapy produced a sustained acceleration in growth rate for a duration of 4 years and eventually has resulted in an increment of mean adult height of 3 cm relative to pre-treatment projected height with mean values of 146.5 cm versus 143.5 cm respectively. The moderate side-effects observed did not cause any of the girls to discontinue treatment. Nevertheless, amelioration of adult height appears to be modest, notably in comparison to published data of growth hormone treatment and 4 girls had a decrease in final height prediction. CONCLUSION Combination of low dose of oxandrolone...Continue Reading

Citations

Apr 3, 2001·Expert Opinion on Investigational Drugs·M C Walter, H Lochmüller
Nov 11, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Eric P SmithKenneth S Korach
Sep 1, 2015·International Journal of Pediatric Endocrinology·Nicole M Sheanon, Philippe F Backeljauw
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Sarar MohamedKhalid AlFaleh

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