Final report of the amended safety assessment of myristic acid and its salts and esters as used in cosmetics

International Journal of Toxicology
Lillian C BeckerF Alan Andersen

Abstract

This report addresses the safety of the inorganic salts and esters of various fatty alcohols of myristic acid. Most of the esters are used as skin conditioning agents in many types of cosmetics in a range of concentrations. Myristate esters are readily hydrolyzed to the corresponding alcohols and acids, which are then further metabolized. Myristate salts readily dissociate in any likely cosmetic formulation. The Cosmetic Ingredient Review (CIR) Panel recognized that much of the data supporting the ingredients in this group were previously reviewed in safety assessments for related ingredients. Where specific data did not exist, the Panel considered structure-activity relationships in determining the safety of these ingredients as used in cosmetics. The Panel determined that myristic acid and its salts and esters are safe as cosmetic ingredients in the current practices of use and concentration.

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Citations

May 30, 2017·International Journal of Toxicology·Christina L BurnettF Alan Andersen
May 30, 2017·International Journal of Toxicology·Christina L BurnettF Alan Andersen
Sep 13, 2015·International Journal of Toxicology·Monice M FiumeF Alan Andersen
Oct 10, 2014·International Journal of Toxicology·Monice M FiumeF Alan Andersen
May 25, 2013·International Journal of Toxicology·Monice M FiumeF Alan Andersen
May 25, 2013·International Journal of Toxicology·Monice M FiumeF Alan Andersen
May 28, 2014·International Journal of Toxicology·Monice M FiumeF Alan Andersen
Oct 14, 2017·International Journal of Toxicology·Monice M FiumeF Alan Andersen
Dec 4, 2016·International Journal of Toxicology·Lillian C BeckerF Alan Andersen
Aug 17, 2021·Journal of Applied Toxicology : JAT·Sonia SanajouTerken Baydar
Aug 11, 2021·Journal of Oleo Science·Minako OkukawaYoshimune Nonomura

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