Final report of the safety assessment of methylisothiazolinone

International Journal of Toxicology
Christina L BurnettF Alan Andersen

Abstract

Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.01%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.

References

Apr 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P GautheronJ F Sina
Oct 1, 1990·The Journal of Applied Bacteriology·P J CóllierP Gilbert
Mar 1, 1989·Contact Dermatitis·M BruzeB Gruvberger
Apr 1, 1987·Contact Dermatitis·M BruzeK Persson
Jul 1, 1995·Contact Dermatitis·M C JacobsJ P McFadden
Feb 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D W Potter, G A Hazelton
Jan 1, 1996·Contact Dermatitis·D P Bruynzeel, C A Verburgh
Dec 25, 2004·Radiology·Masahiro JinzakiSachio Kuribayashi
Jun 22, 2006·Contact Dermatitis·J P ThyssenT Menné

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Citations

Jan 16, 2016·Contact Dermatitis·Antoine BadaouiCatherine Pecquet
Aug 19, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R MesnageG E Séralini
Mar 19, 2016·Environmental Health and Toxicology·Yeyong Choi, Domyung Paek
Apr 13, 2011·Contact Dermatitis·Cristina AmaroJorge Cardoso
Jun 21, 2013·Contact Dermatitis·John P McFaddenIan R White
Jul 23, 2011·The British Journal of Dermatology·M D LundovJ D Johansen
Feb 22, 2011·The British Journal of Dermatology·A SchnuchW Uter
Apr 23, 2013·Contact Dermatitis·Margarida Gonçalo, An Goossens
Apr 16, 2014·Contact Dermatitis·Stéphanie HosteingUNKNOWN REVIDAL-GERDA network
Aug 11, 2015·Contact Dermatitis·Olivier AertsSandra Apers
Apr 25, 2015·Toxicology Letters·Fien C DevosJeroen A J Vanoirbeek
Jul 31, 2016·BMC Ophthalmology·Nicholas CookIan A Cree
Jan 26, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·T SchettgenT Kraus
Nov 30, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A M Giménez-ArnauW Uter
Sep 11, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Elizabeth YimAntonella Tosti
May 27, 2017·Current Opinion in Allergy and Clinical Immunology·Gustavo Deza, Ana M Giménez-Arnau
Jan 24, 2017·Environmental Health and Toxicology·Sungkyoon Kim, Domyung Paek
Sep 10, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Zhiwei ShenYi Zhang
Jan 24, 2013·Dermatitis : Contact, Atopic, Occupational, Drug·Mari Paz Castanedo-Tardana, Kathryn A Zug
Aug 15, 2020·International Journal of Toxicology·Douglas J Ball, William P Beierschmitt
May 5, 2017·Archives of Toxicology·Aurélie BerthetNancy B Hopf
Nov 8, 2020·Regulatory Toxicology and Pharmacology : RTP·Hung-Lin KanChun-Wei Tung
Feb 14, 2021·Journal of the American Academy of Dermatology·Amber Reck AtwaterErin M Warshaw
Feb 25, 2021·Journal of Applied Toxicology : JAT·Andrezza Di Pietro Micali CanavezMarcio Lorencini

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