Final Report of Unmet Needs of Interferon-Based Therapy for Chronic Hepatitis C in Korea: Basis for Moving into the Direct-Acting Antiviral Era

Gut and Liver
Eun Sun JangSook-Hyang Jeong

Abstract

To evaluate the era of direct acting antivirals (DAAs), we must understand the treatment patterns and outcomes of interferon-based therapy for hepatitis C virus (HCV) infection. We aimed to elucidate the treatment rate, factors affecting treatment decisions, and efficacy of interferon- based therapy in a real-world setting. This nationwide cohort study included 1,191 newly diagnosed patients with chronic HCV infection at seven tertiary hospitals in South Korea. Subjects were followed retrospectively until March 2015, which was just before the approval of DAA therapy. In total, 48.2% and 49.3% of the patients had HCV genotypes 1 and 2, respectively. Interferon-based therapy was initiated in 541 patients (45.4%). The major reasons for no treatment included ineligibility (18.9%), concern about adverse events (22.3%), cost (21.5%), and an age >75 years (19.5%). Interferon-based therapy was discontinued (18.5%) mainly due to adverse events (n=66). The intent-to-treat analysis found that the sustained virologic response (SVR) rate was 58.3% in genotype 1 patients and 74.7% in nongenotype 1 patients. Approximately one-third of newly diagnosed HCV patients in South Korea received interferon-based therapy and showed a suboptimal SVR rat...Continue Reading

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Citations

Aug 5, 2017·Epidemiology and Health·Sook-Hyang JeongMoran Ki
Jul 13, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Kyung-Ah KimSook-Hyang Jeong
Nov 22, 2018·Journal of Gastroenterology and Hepatology·Wankyo ChungSook-Hyang Jeong
Aug 23, 2019·Hepatology International·Eun Sun JangUNKNOWN Korean hepatitis epidemiology study group
Aug 17, 2019·Eye and Vision·Ghada Al BayyatCarol L Karp
Dec 5, 2017·Euroasian Journal of Hepato-gastroenterology·Stella C PakUmar Darr

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