Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate

International Journal of Toxicology
Wilbur Johnson

Abstract

Octoxynols are ethoxylated alkylphenols in which the size of the molecule is related to the number of moles of ethylene oxide used in synthesis. Reactions are performed at elevated temperature, under pressure, and in the presence of NaOH. It is possible that the synthesis may leave trace amounts of ethylene oxide, 1,4-dioxane, and unreacted C9 phenols. Octoxynols of various chain lengths as well as octoxynol salts and organic acids function in cosmetics either as surfactants--emulsifying agents, surfactants--cleansing agents, surfactant--solubilizing agents, or surfactants--hydrotropes in a wide variety of cosmetic products at concentrations ranging from 0.0008% to 25%, with most less than 5.0%. The octoxynols are chemically similar to nonoxynols, the safety of which were previously considered. Long-chain nonoxynols (9 and above) were considered safe as used, whereas short-chain nonoxynols (8 and below) were considered safe as used in rinse-off products and safe at concentrations less than 5% in leave-on formulations. Acute exposure of hamsters to Octoxynol-9 by bronchopulmonary lavage produced pneumonia, pulmonary edema, and intra-alveolar hemorrhage. Octoxynol-9 at doses over 1 g/kg was toxic in rats and in mice in acute oral...Continue Reading

References

Sep 1, 1978·Archives of Dermatology·J S StraussE H Gans
May 1, 1978·Toxicology and Applied Pharmacology·R F HendersonT R Henderson
Jul 1, 1991·Sexually Transmitted Diseases·S NiruthisardS Chutivongse
Jul 15, 1990·Thrombosis Research·F RodeghieroP M Mannucci
Aug 17, 1990·Biochimica Et Biophysica Acta·J Bielawski
May 1, 1989·Contact Dermatitis·Y Kabasawa, T Kanzaki
Oct 1, 1989·Journal of the American Academy of Dermatology·A Dooms-GoossensH Degreef
Feb 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·H E KennahC S Barrow
Jan 1, 1988·Environmental and Molecular Mutagenesis·C W SheuV C Dunkel
Apr 1, 1988·Pharmacology & Toxicology·O MeyerJ C Larsen
Nov 1, 1988·Toxicology and Applied Pharmacology·B A WalterG A Digenis
Jan 1, 1987·Teratogenesis, Carcinogenesis, and Mutagenesis·B D HardinK N Smith
Aug 20, 1987·The New England Journal of Medicine·C LouikS Shapiro
Jul 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M KaminskyD A Willigan
Feb 1, 1987·Toxicology Letters·L D Caren, V Brunmeier
May 1, 1988·Mutagenesis·J Wangenheim, G Bolcsfoldi
Aug 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P UkkonenK Hedman
Jun 15, 1987·The Biochemical Journal·D Trägner, A Csordas
Oct 1, 1986·Journal of Biochemical and Biophysical Methods·J A Boutin
Jun 22, 1987·Biochimica Et Biophysica Acta·M HardyL Douste-Blazy
Jan 1, 1970·International Archives of Allergy and Applied Immunology·L G Wiest, E G Jung
Oct 1, 1967·Food and Cosmetics Toxicology·C G Hunter, D E Stevenson
Sep 1, 1966·Toxicology and Applied Pharmacology·J B KnaakL J Sullivan
Aug 1, 1981·Fertility and Sterility·M M Dolan
May 29, 1981·Biochemical and Biophysical Research Communications·R K Sharma, J H Wang
Feb 1, 1982·Fertility and Sterility·M ChvapilD L Earnest
May 7, 1982·JAMA : the Journal of the American Medical Association·S ShapiroS P Helmrich
Sep 1, 1982·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L Tryphonas, H S Buttar
Feb 1, 1984·Archives of Biochemistry and Biophysics·M C BarberoJ M Macarulla
Mar 1, 1984·Toxicology Letters·L Tryphonas, H S Buttar
Apr 1, 1984·Contact Dermatitis·J R Nethercott, M J Lawrence
Apr 1, 1984·Applied and Environmental Microbiology·K T Schappert, G G Khachatourians
Jan 1, 1980·International Archives of Allergy and Applied Immunology·J SzymaniecZ Wieczorek
Apr 3, 1981·JAMA : the Journal of the American Medical Association·H JickS Madsen
Mar 1, 1980·Journal of Biochemical and Biophysical Methods·D A Whitmore, K P Wheeler
Jun 1, 1995·Physics in Medicine and Biology·P M BloomfieldJ Young
Apr 1, 1995·Journal of Pharmacological and Toxicological Methods·R L OberleD A Krummel
Feb 1, 1994·Scandinavian Journal of Gastroenterology·S NagoshiK Fujiwara
May 1, 1996·Clinical Orthopaedics and Related Research·J J RodrigoN A Sharkey
May 1, 1996·Critical Reviews in Toxicology·A C Nimrod, W H Benson
Apr 1, 1996·Neurochemical Research·M GrabowR W Ledeen
Apr 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S D Carson
Apr 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S D CarsonS J Pirruccello
Feb 1, 1997·Yonsei Medical Journal·J M AhnJ H Park
Aug 10, 1999·Journal of Applied Toxicology : JAT·H W Leung, B Ballantyne
Jul 11, 2000·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·B S Panigrahi
Oct 1, 1989·International Journal of Cosmetic Science·P TachonM Prunieras
Jun 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H KojimaI Yoshimura
Jan 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Gülden

Citations

May 23, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Manigé FartaschSibylle Schliemann
Jul 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chad P NelsonMichelle L Twaroski
Jun 18, 2011·Journal of Veterinary Pharmacology and Therapeutics·V GoettingL A Tell

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