Finale: the last minutes of Smads

Cell
Ye-Guang Chen, Xiao-Fan Wang

Abstract

TGF-beta ligands induce phosphorylation of receptor-activated Smads at both the C-terminal tail and the linker region. Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009) reveal a dual role for this linker phosphorylation, which is required for activation of Smads and for their degradation.

References

Oct 6, 1998·Annual Review of Biochemistry·J Massagué

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Citations

Aug 10, 2011·Molecular and Cellular Biology·Lan Xu
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Elsa PapadimitriouChristos Stournaras
Oct 20, 2009·Cell·Hans Clevers
Mar 3, 2010·Immunological Reviews·R Maarten EgelerPieter J M Leenen

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