Finding a Missing Gene: EFG1 Regulates Morphogenesis in Candida tropicalis

G3 : Genes - Genomes - Genetics
Eugenio ManceraAlexander D Johnson

Abstract

Fungi from the genus Candida are common members of the human microbiota; however, they are also important opportunistic pathogens in immunocompromised hosts. Several morphological transitions have been linked to the ability of these fungi to occupy the different ecological niches in the human body. The transcription factor Efg1 from the APSES family plays a central role in the transcription circuits underlying several of these morphological changes. In Candida albicans, for example, Efg1 is a central regulator of filamentation, biofilm formation, and white-opaque switching, processes associated with survival in the human host. Orthologs of Efg1 are present throughout the Candida clade but, surprisingly, the genome sequence of Candida tropicalis failed to uncover a gene coding for Efg1. One possibility was that the paralog of Efg1, Efh1, had assumed the function of Efg1 in C. tropicalis. However, we show that this gene has only a minor role in the morphological transitions mentioned above. Instead, we report here that C. tropicalis does have an ortholog of the EFG1 gene found in other Candida species. The gene is located in a different genomic position than EFG1 in C. albicans, in a region that contains a gap in the current geno...Continue Reading

References

Jan 1, 1991·Annual Review of Microbiology·J E Cutler
Sep 23, 1997·Cell·H J LoG R Fink
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Donlan
Apr 5, 2002·Clinical Microbiology Reviews·Rodney M Donlan, J William Costerton
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chung-Yu LanNina Agabian
Jan 17, 2003·Genome Research·David B JaffeEric S Lander
Apr 16, 2004·Clinical Microbiology Reviews·Erna M Kojic, Rabih O Darouiche
Jun 26, 2004·Molecular Biology of the Cell·Thomas DoedtJoachim F Ernst
Oct 12, 2004·Gene·Oliver ReussJoachim Morschhäuser
Jun 26, 2007·Molecular Genetics and Genomics : MGG·Prashant K MishraJohn Carbon
Sep 21, 2007·PLoS Biology·Rebecca E ZordanAlexander D Johnson
May 26, 2009·Nature·Geraldine ButlerChristina A Cuomo
Oct 27, 2009·Current Opinion in Microbiology·Matthew B Lohse, Alexander D Johnson
Dec 30, 2010·Nature Reviews. Microbiology·Jonathan S Finkel, Aaron P Mitchell
Aug 17, 2011·Nature Reviews. Microbiology·Peter E Sudbery
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Allison M PormanRichard J Bennett
Mar 15, 2013·Molecular Biology and Evolution·Sarah L MaguireGeraldine Butler
Jul 17, 2013·Molecular Microbiology·Aaron D HerndayAlexander D Johnson
Aug 6, 2013·Eukaryotic Cell·Erika LackeyDavid Kadosh
Dec 17, 2014·Genome Research·Matthew P HirakawaChristina A Cuomo

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Citations

Dec 20, 2017·Virulence·Chi-Jan LinYing-Lien Chen
Apr 11, 2019·Acta Biochimica Et Biophysica Sinica·Jiao GongGuanghua Huang
Sep 25, 2018·Mini Reviews in Medicinal Chemistry·Małgorzata GizińskaZbigniew Ochal
Sep 24, 2019·Current Protein & Peptide Science·Staniszewska Monika
Oct 16, 2015·Molecular Microbiology·Qiuyu ZhangGuanghua Huang
Jun 29, 2017·Annual Review of Microbiology·Kenneth H Wolfe, Geraldine Butler
Apr 4, 2019·Frontiers in Microbiology·Eugenio ManceraRichard J Bennett
Dec 7, 2019·The Journal of Biological Chemistry·Sabrina S SchatzmanValeria C Culotta
Oct 31, 2017·Frontiers in Microbiology·Diana L Zuza-AlvesGuilherme M Chaves
Jun 21, 2020·Microbial Pathogenesis·AlaneT P MoralezMarcia C Furlaneto

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Datasets Mentioned

BETA
KP314278
KP314279

Methods Mentioned

BETA
PCR
confocal microscopy

Software Mentioned

Seaview
CGOB
MUSCLE
PhyML

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