Finding a Toll on the Route: The Fate of Osteoclast Progenitors After Toll-Like Receptor Activation

Frontiers in Immunology
Pedro P C Souza, Ulf H Lerner

Abstract

M-CSF and RANKL are two crucial cytokines stimulating differentiation of mature, bone resorbing, multinucleated osteoclasts from mononucleated progenitor cells in the monocyte/macrophage lineage. In addition to the receptors for M-CSF and RANKL, osteoclast progenitor cells express receptors for several other pro- and anti-osteoclastogenic cytokines, which also regulate osteoclast formation by affecting signaling downstream M-CSF and RANKL receptors. Similar to many other cells originating from myeloid hematopoetic stem cells, also osteoclast progenitors express toll-like receptors (TLRs). Nine murine TLRs are expressed in the progenitors and all, with the exception of TLR2 and TLR4, are downregulated during osteoclastogenesis. Activation of TLR2, TLR4, and TLR9, but not TLR5, in osteoclast progenitors stimulated with M-CSF and RANKL arrests differentiation along the osteoclastic lineage and keeps the cells at a macrophage stage. When the progenitors are primed with M-CSF/RANKL and then stimulated with agonists for TLR2, TLR4, or TLR9 in the presence of M-CSF, but in the absence of RANKL, the cells differentiate to mature, bone resorbing osteoclasts. TLR 2, 4, 5, and 9 are also expressed on osteoblasts and their activation incre...Continue Reading

References

May 30, 1991·Nature·N J Gay, F J Keith
Nov 1, 1989·Journal of Periodontal Research·A UmezuH Itoh
May 15, 1970·Science·E HausmannW A Miller
Mar 1, 1993·The American Journal of Physiology·P OrcelM C De Vernejoul
Jul 1, 1996·Infection and Immunity·S P NairB Henderson
Sep 18, 1997·The Journal of Clinical Investigation·Y Abu-AmerS L Teitelbaum
Nov 25, 1997·Journal of Cellular Physiology·S AmanoS Hanazawa
Jan 8, 1999·Biochemical and Biophysical Research Communications·N NakagawaK Higashio
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HsuW J Boyle
Apr 10, 1999·The Journal of Biological Chemistry·J C ChowF Gusovsky
May 4, 1999·The Journal of Cell Biology·T L BurgessD L Lacey
Sep 29, 1999·Genes & Development·W C DougallJ Schuh
Nov 24, 1999·The Journal of Biological Chemistry·E LienD T Golenbock
Dec 29, 2000·Nature·H HemmiS Akira
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T KikuchiY Yoshikai
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·N J HorwoodM T Gillespie
Feb 28, 2002·Annual Review of Immunology·Lars E TheillJosef M Penninger
Mar 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei ZouZvi Bar-Shavit
Apr 19, 2002·Nature·Hiroshi TakayanagiTadatsugu Taniguchi
Jul 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei Zou, Zvi Bar-Shavit
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masamichi TakamiYongwon Choi
Mar 4, 2003·The Journal of Biological Chemistry·Wei ZouZvi Bar-Shavit
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kanami ItohNaoyuki Takahashi
Oct 14, 2003·Trends in Immunology·Jessica K BellDavid M Segal
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin-Ichi HayashiHidetoshi Yamazaki
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Aug 2, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alla AmcheslavskyZvi Bar-Shavit
Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Jan 13, 2006·Journal of Cellular Physiology·Alla Amcheslavsky, Zvi Bar-Shavit

❮ Previous
Next ❯

Citations

May 7, 2020·Journal of Cellular Physiology·Palani DineshMahaboobkhan Rasool
Dec 16, 2020·Journal of Bone Metabolism·Mijung Yim
Jan 10, 2021·Molecular Genetics and Metabolism·Gregory A GrabowskiPramod K Mistry
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wataru AriyoshiRyota Yamasaki
Jun 3, 2021·International Journal of Molecular Sciences·Yeongkag KwonSeung Hyun Han
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingyun LuXijie Yu
Jun 29, 2021·Frontiers in Immunology·Yang LiQianzhou Jiang
Jul 31, 2021·Journal of Dental Research·N Da Ponte LeguizamónJ A Cirelli
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Zhou FanLinhu Ge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Immunological Investigations
Pedro P C Souza, Ulf H Lerner
Methods in Molecular Biology
N UdagawaNaoyuki Takahashi
The Journal of Immunology : Official Journal of the American Association of Immunologists
Masamichi TakamiYongwon Choi
Journal of Bone Metabolism
Jung Ha Kim, Nacksung Kim
© 2021 Meta ULC. All rights reserved