Finding Hybrid Incompatibilities Using Genome Sequences from Hybrid Populations.

Molecular Biology and Evolution
Alexandre Blanckaert, Bret A Payseur

Abstract

Natural hybrid zones offer a powerful framework for understanding the genetic basis of speciation in progress because ongoing hybridization continually creates unfavorable gene combinations. Evidence indicates that postzygotic reproductive isolation is often caused by epistatic interactions between mutations in different genes that evolved independently of one another (hybrid incompatibilities). We examined the potential to detect epistatic selection against incompatibilities from genome sequence data using the site frequency spectrum (SFS) of polymorphisms by conducting individual-based simulations in SLiM. We found that the genome-wide SFS in hybrid populations assumes a diagnostic shape, with the continual input of fixed differences between source populations via migration inducing a mass at intermediate allele frequency. Epistatic selection locally distorts the SFS as non-incompatibility alleles rise in frequency in a manner analogous to a selective sweep. Building on these results, we present a statistical method to identify genomic regions containing incompatibility loci that locates departures in the local SFS compared with the genome-wide SFS. Cross-validation studies demonstrate that our method detects recessive and co...Continue Reading

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References

Dec 1, 1986·Heredity·N Barton, B O Bengtsson
Jul 28, 2001·Evolution; International Journal of Organic Evolution·H A Orr, M Turelli
Nov 16, 2005·Annual Review of Genetics·Rasmus Nielsen
Jul 1, 1938·Proceedings of the National Academy of Sciences of the United States of America·S Wright
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Ohta
Nov 25, 2006·Science·Nicholas J BrideauDaniel A Barbash
Jun 5, 2007·PLoS Genetics·Scott H WilliamsonRasmus Nielsen
Nov 21, 2007·Genome Research·Katherine C TeeterPriscilla K Tucker
Dec 17, 2008·Science·Ondrej MiholaJiri Forejt
Feb 27, 2009·Molecular Ecology·Zachariah Gompert, C Alex Buerkle
Jan 7, 2010·Nature Reviews. Genetics·Daven C Presgraves
Sep 18, 2010·Science·Leonie C Moyle, Takuya Nakazato
Apr 2, 2011·Molecular Ecology·Zachariah Gompert, C Alex Buerkle
Sep 14, 2011·Annual Review of Genetics·Shamoni Maheshwari, Daniel A Barbash
Dec 14, 2011·Trends in Ecology & Evolution·Asher D Cutter
Jan 12, 2013·Science·Christopher H Martin, Peter C Wainwright
Nov 30, 2013·Molecular Biology and Evolution·Eunjung HanJohn Novembre
Jul 23, 2015·Genetics·Richard J WangBret A Payseur
Feb 3, 2016·Molecular Ecology·Bret A Payseur, Loren H Rieseberg
Apr 3, 2016·Genetics·Kelley Harris, Rasmus Nielsen
Apr 12, 2016·Molecular Ecology·Molly Schumer, Yaniv Brandvain
Jun 13, 2017·PLoS Genetics·Rafael F GuerreroLeonie C Moyle
Dec 6, 2018·Molecular Biology and Evolution·Benjamin C Haller, Philipp W Messer
Jul 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alexandre BlanckaertJoachim Hermisson
Nov 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yuan LuRonald Walter
Feb 24, 2021·Current Biology : CB·G Ozan BozdagDuncan Greig

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