Finding the Elusive Psychiatric "Lesion" With 21st-Century Neuroanatomy: A Note of Caution

The American Journal of Psychiatry
Daniel R Weinberger, Eugenia Radulescu

Abstract

The widespread use of MRI has led to a wealth of structural and functional anatomical findings in patients with diverse psychiatric disorders that may represent insights into pathobiology. However, recent technical reports indicate that data from popular MRI research-particularly structural MRI, resting--state functional MRI, and diffusion tensor imaging--are highly sensitive to common artifacts (e.g., head motion and breathing effects) that may dominate the results. Because these and other important confounders of MRI data (e.g., smoking, body weight, metabolic variations, medical comorbidities, psychoactive drugs, alcohol use, mental state) tend to vary systematically between patient and control groups, the evidence that findings are neurobiologically meaningful is inconclusive and may represent artifacts or epiphenomena of uncertain value. The authors caution that uncritically accepting from study to study findings that may represent fallacies of all sorts carries the risk of misinforming practitioners and patients about biological abnormalities underlying psychiatric illness.

Citations

Feb 20, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Maarten Mennes
May 21, 2016·Frontiers in Human Neuroscience·Georg Northoff, Giovanni Stanghellini
May 15, 2016·Psychiatry Research. Neuroimaging·Andia H TurnerTheo G M van Erp
Aug 24, 2016·Journal of Psychiatric Research·Lisa M McTeagueAmit Etkin
Aug 28, 2016·Schizophrenia Research·Karl-Anton Dorph-Petersen, David A Lewis
Sep 17, 2016·Omics : a Journal of Integrative Biology·Shareefa DalvieDan J Stein
Oct 5, 2016·Depression and Anxiety·Andrea L GoldJennifer C Britton
Oct 27, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Henrik Nørbak-EmigBjørn H Ebdrup
Nov 9, 2016·Translational Psychiatry·N Mechawar, J Savitz
Nov 12, 2016·Expert Review of Clinical Pharmacology·Eileen Thomas, Dan J Stein
Apr 2, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Georg Northoff
Apr 6, 2018·Journal of Clinical Psychopharmacology·Ronald W Pies
Oct 27, 2017·Nature Reviews. Neuroscience·Rebecca Birnbaum, Daniel R Weinberger
Oct 19, 2017·Schizophrenia Bulletin·Daniel R Weinberger
Nov 29, 2017·Genome Medicine·Mary S MuffordNeda Jahanshad
Oct 8, 2017·International Journal of Offender Therapy and Comparative Criminology·Paul B Jantz, Richard H Morley
Dec 6, 2017·Molecular Psychiatry·D A MoserS Frangou
Feb 17, 2018·Nature Reviews. Neuroscience·John H GilmoreWei Gao
May 18, 2019·Expert Review of Neurotherapeutics·Mbemba Jabbi, Charles B Nemeroff
Jul 18, 2019·Human Brain Mapping·Teresa M KarrerDanilo Bzdok
Nov 23, 2019·Schizophrenia Bulletin·Federico E TurkheimerAnthony C Vernon
Aug 12, 2016·Human Brain Mapping·Simon B EickhoffPeter T Fox
Jul 4, 2020·Human Brain Mapping·Janna Marie Bas-HoogendamUNKNOWN ENIGMA-Anxiety Working Group
Jul 23, 2020·JAMA Psychiatry·Daniel R Weinberger, Eugenia Radulescu
Sep 2, 2020·The American Journal of Psychiatry·Ned H Kalin
Nov 8, 2016·Frontiers in Human Neuroscience·Robert T Thibault, Amir Raz
Apr 19, 2017·The Australian and New Zealand Journal of Psychiatry·Bruno DietscheIrina Falkenberg
Jul 22, 2018·Frontiers in Pharmacology·Eduardo Ekman Schenberg
May 1, 2019·Frontiers in Psychiatry·Mingli LiTao Li
Jul 2, 2019·The American Journal of Psychiatry·Edward Bullmore

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