Finding the optimal dose reduction and iterative reconstruction level for coronary calcium scoring

Journal of Cardiovascular Computed Tomography
Martin J WilleminkTim Leiner

Abstract

To assess the maximally achievable computed tomography (CT) dose reduction for coronary artery calcium (CAC) scoring with iterative reconstruction (IR) by using phantom-experiments and a systematical within-patient study. Our local institutional review-board approved this study and informed consent was obtained from all participants. A phantom and patient study were conducted with 30 patients (23 men, median age 55.0 (52.0-56.0) years) who underwent 256-slice electrocardiogram-triggered CAC-scoring at four dose levels (routine, 60%, 40%, and 20%-dose) in a single session. Tube-voltage was 120 kVp, tube-current was lowered to achieve stated dose levels. Data were reconstructed with filtered back-projection (FBP) and three IR levels. Agatston, volume and mass scores were determined with validated software and compared using Wilcoxon signed ranks-tests. Subsequently, patient reclassification was analyzed. The phantom study showed that Agatston scores remained nearly stable with FBP between routine-dose and 40%-dose and increased substantially at lower dose. Twenty-three patients (77%) had coronary calcifications. For Agatston scoring, one 40%-dose and six 20%-dose FBP reconstructions were not interpretable due to noise. In contras...Continue Reading

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Citations

Feb 29, 2016·Current Cardiology Reports·Martin J WilleminkPál Maurovich-Horvat
Mar 8, 2017·European Journal of Radiology·E PompeF A A Mohamed Hoesein
May 8, 2018·Expert Review of Cardiovascular Therapy·Christian TescheChristian Thilo
Jun 3, 2017·IEEE Transactions on Medical Imaging·Jelmer M WolterinkIvana Isgum
Jul 24, 2018·Journal of Thoracic Imaging·Damiano CarusoAndrea Laghi
Aug 26, 2016·Journal of Computer Assisted Tomography·Robbert Willem van HamersveltPim A de Jong
Apr 27, 2020·The International Journal of Cardiovascular Imaging·Ricarda HinzpeterMatthias Eberhard
Mar 8, 2020·Journal of Nuclear Medicine Technology·Paul MadajMatthew J Budoff

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