May 28, 2015

Finding the positive feedback loops underlying multi-stationarity

BMC Systems Biology
Elisenda Feliu, Carsten Wiuf

Abstract

Bistability is ubiquitous in biological systems. For example, bistability is found in many reaction networks that involve the control and execution of important biological functions, such as signaling processes. Positive feedback loops, composed of species and reactions, are necessary for bistability, and generally for multi-stationarity, to occur. These loops are therefore often used to illustrate and pinpoint the parts of a multi-stationary network that are relevant ('responsible') for the observed multi-stationarity. However positive feedback loops are generally abundant in reaction networks but not all of them are important for understanding the network's dynamics. We present an automated procedure to determine the relevant positive feedback loops of a multi-stationary reaction network. The procedure only reports the loops that are relevant for multi-stationarity (that is, when broken multi-stationarity disappears) and not all positive feedback loops of the network. We show that the relevant positive feedback loops must be understood in the context of the network (one loop might be relevant for one network, but cannot create multi-stationarity in another). Finally, we demonstrate the procedure by applying it to several exam...Continue Reading

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Mentioned in this Paper

Apoptosis, Intrinsic Pathway
Metabolic Networks and Pathways
Apoptosis
PRC1 Complex Location
Loop
Feedback, Biochemical
Species
Signal Transduction
Computational Molecular Biology
Ubiquitination

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