DOI: 10.1101/507665Dec 31, 2018Paper

FinDonor 10 000 study: A cohort to identify iron depletion and factors affecting it in Finnish blood donors

BioRxiv : the Preprint Server for Biology
Muriel LobierMikko Arvas

Abstract

Background and Objectives: There is increasing evidence that frequent blood donation depletes the iron stores of some blood donors. The FinDonor 10 000 study was set up to study iron status and factors affecting iron stores in Finnish blood donors. In Finland, iron supplementation for at-risk groups has been in place since the 1980's. Material and Methods: 2584 blood donors (N= 8003 samples) were recruited into the study alongside the standard donation at three donation sites in the capital region of Finland between 5/2015 and 12/2017. All participants were asked to fill out a questionnaire about their health and lifestyle. Blood samples were collected from the sample pouch of whole blood collection set, kept in cool temperature and processed centrally. Whole blood count, CRP, ferritin and sTFR were measured from the samples and DNA was isolated for GWAS studies. Results: Participant demographics, albeit in general similar to the general blood donor population in Finland, indicated some bias toward older and more frequent donors. Participation in the study increased median donation frequency of the donors. Analysis of the effect of time lag from the sampling to the analysis and the time of day when sample was drawn revealed sma...Continue Reading

Related Concepts

Blood
Blood Donation
Blood Donor
C-reactive protein
DNA
Donor Person
Ferritin
Blood Specimen
Site
Iron Deficiency

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