Fine control on the photochemical and photobiological properties of Ru(II) arene complexes

Dalton Transactions : an International Journal of Inorganic Chemistry
Yongjie ChenXue-Song Wang

Abstract

A series of six Ru(arene) complexes, [(η(6)-p-cymene)Ru(dpb)(py-R)](2+) (1-6, dpb = 2,3-bis(2-pyridyl)benzoquinoxaline, py-R = 4-substituted pyridine, R = N(CH3)2, NH2, OCH3, H, COOCH3 and NO2), were synthesized and their photochemical and photobiological properties were compared in detail. The electron push/pull character of the R groups has a significant impact on both ligand photodissociation and (1)O2 generation of the complexes. The photoinduced DNA covalent binding capabilities increase from 1 to 6 under both aerobic and anaerobic conditions, and DNA photocleavage occurs simultaneously in aerobic environments. 4 has the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. The substituent effect may be ascribed to the influences of the R groups on the energy levels of (3)MC and (3)MLCT states as well as the energy gaps between (3)MC, (3)MLCT and dpb-based (3)IL states. Similar chemical modification on bidentate and arene ligands or other sites of the pyridine ligand may lead to more efficient agents with PDT and/or PACT activities.

References

Sep 30, 1976·Nature·Y LionA van de Vorst
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Jul 23, 2004·Journal of Medicinal Chemistry·Michael R DettyStephen J Wagner
Feb 27, 2008·Journal of Medicinal Chemistry·Frédéric SchmittBruno Therrien
Jul 16, 2009·The Journal of Physical Chemistry. B·Qian-Xiong ZhouBao-Wen Zhang
Aug 18, 2009·Photochemistry and Photobiology·Aisling E O'ConnorAnnette T Byrne
Sep 18, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa GianferraraEnzo Alessio
Oct 30, 2009·Chemical Communications : Chem Comm·Soledad Betanzos-LaraPeter J Sadler
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa GianferraraEnzo Alessio
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
May 25, 2010·Journal of Medicinal Chemistry·Teresa GianferraraEnzo Alessio
Aug 18, 2010·Physical Chemistry Chemical Physics : PCCP·Guo-Yu JiangBao-Wen Zhang
Aug 19, 2010·Chemical Communications : Chem Comm·Daniel CrespyAlexander Schiller
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Jun 15, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhiming Xu, Shawn Swavey
Sep 2, 2011·Inorganic Chemistry·Robert N GarnerClaudia Turro
Nov 10, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Yi SunXue-Song Wang
Dec 14, 2011·Bioorganic & Medicinal Chemistry Letters·Frédéric SchmittBruno Therrien
Mar 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Patrick SweigertShawn Swavey
May 5, 2012·Journal of the American Chemical Society·Brock S HowertonEdith C Glazer
May 24, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jianguang WangXuesong Wang
Jun 16, 2012·Chemistry : a European Journal·Qianxiong ZhouXuesong Wang
Aug 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Živadin D BugarčićRudi van Eldik
Sep 19, 2012·Chemistry : a European Journal·Jimmy Suryadi, Ulrich Bierbach
Dec 18, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Qian-Xiong ZhouXue-Song Wang
Mar 6, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Yongjie ChenXuesong Wang
May 3, 2013·Chemical Communications : Chem Comm·Nicolas P E Barry, Peter J Sadler
Oct 17, 2013·Journal of the American Chemical Society·Richard LincolnSherri A McFarland
Nov 15, 2013·Chemical Communications : Chem Comm·Erin WachterEdith C Glazer
Sep 5, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Yongjie ChenXuesong Wang
Sep 10, 2014·Inorganic Chemistry·Achmad N HidayatullahEdith C Glazer
Sep 13, 2014·Chemistry : a European Journal·Cristina MariGilles Gasser
Nov 25, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ke LiXuesong Wang
Dec 2, 2014·Journal of the American Chemical Society·Zhanyong LiKim R Dunbar

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