Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population

Epigenomics
Xing FanNicholas J Schork

Abstract

A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. We used least absolute shrinkage and selection operator (LASSO)-based regression analysis to assess independent contributions of 2171 variants to psoriasis susceptibility and tested them for association with different clinical psoriasis subtypes. We found that ADRA1B gene variants contribute to psoriasis in Chinese population. ADRA1B gene variants have a stronger association with moderate-to-severe disease group and an earlier age at onset of psoriasis than IL-12B and PTTG1 variants. The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis.

References

Sep 1, 1985·Journal of the American Academy of Dermatology·T Henseler, E Christophers
Dec 18, 1998·The Journal of Investigative Dermatology·N YawalkarL R Braathen
Jun 26, 2001·Clinical and Experimental Dermatology·E Christophers
Jan 7, 2004·The Journal of Experimental Medicine·Edmund LeeJames G Krueger
Mar 28, 2008·Human Molecular Genetics·Francesca CaponRichard C Trembath
Jan 27, 2009·Nature Genetics·Rajan P NairUNKNOWN Collaborative Association Study of Psoriasis
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Sep 22, 2010·Archives of Dermatological Research·U MrowietzN Yawalkar
Oct 19, 2010·Nature Genetics·Eva EllinghausAndre Franke
Oct 19, 2010·Nature Genetics·Philip E StuartJames T Elder
Oct 19, 2010·Nature Genetics·UNKNOWN Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2Richard C Trembath
Nov 26, 2010·Genetic Epidemiology·Kristin L Ayers, Heather J Cordell
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Jan 19, 2012·Nature Reviews. Genetics·Greg Gibson
Apr 10, 2015·Nature Communications·Xianbo ZuoXuejun Zhang
Oct 27, 2015·BMC Bioinformatics·Yining WangGuohui Lin

❮ Previous
Next ❯

Citations

Dec 21, 2019·Molecular Genetics & Genomic Medicine·Jianxiao XingKaiming Zhang
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lin ZhouDisheng Tao

❮ Previous
Next ❯

Methods Mentioned

BETA
Chips
genotyping

Software Mentioned

R
Plink
LASSO
R package glmnet
R package pROC
IMPUTE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.