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Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

Human Molecular Genetics

Mar 29, 2013

Zsofia Kote-JaraiRosalind A Eeles

Abstract

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT)...read more

Mentioned in this Paper

Prostatic Neoplasms
Telomerase Catalytic Subunit
Promoter
TERT gene
Prostate Carcinoma
Proximal Right Coronary Artery Conduit
Genome Mapping
Multiple Malignancy
Chromosomes, Human, Pair 5
Telomerase
1
13
1
119
Paper Details
References
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  • Citations54
123
  • References25
  • Citations54
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Telomere Elongation

Telomere elongation by telomerase counteracts the telomere shortening due to the incomplete replication of chromosome ends by dna polymerase.

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Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

Human Molecular Genetics

Mar 29, 2013

Zsofia Kote-JaraiRosalind A Eeles

PMID: 23535824

DOI: 10.1093/hmg/ddt086

Abstract

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT)...read more

Mentioned in this Paper

Prostatic Neoplasms
Telomerase Catalytic Subunit
Promoter
TERT gene
Prostate Carcinoma
Proximal Right Coronary Artery Conduit
Genome Mapping
Multiple Malignancy
Chromosomes, Human, Pair 5
Telomerase
1
13
1
119

Feeds With Similar Papers

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

International Cancer Genome Consortium

The International Cancer Genome Consortium (ICGC) was founded with the goal of mapping the genome of 25,000 primary untreated cancers. The ICGC has also pushed for the global sharing of genomic data to facilitate cancer research. Find the latest research from the ICGC here.

Related Papers

Paper Details
References
  • References25
  • Citations54
123
  • References25
  • Citations54
12345...

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