Fine mapping of 39 ESTs on human chromosome 6p23-p25

Genomics
M G OlavesenJ Ragoussis

Abstract

Loci conferring susceptibility to schizophrenia, coeliac disease, and orofacial clefting have been assigned to the 6p23-p25 region of human chromosome 6. To facilitate the identification of candidate genes we have sublocalized and ordered 39 ESTs assigned to this interval by radiation hybrid mapping. This was achieved by generating PAC contigs containing the ESTs, genetic markers, and random STSs. For full integration into previously published data a single YAC contig spanning 6p23-p25 was used to unambiguously order the PAC contigs and ESTs along the chromosome. The majority of the ESTs (31/39) were positioned in the 6p23-p24 interval at the proximal half of the map, and of these 8 are located within a single PAC clone. The order of known genes in this region is cen-CD83-ZNF40-EDN1-(GCNT2, CAPZB)-TFAP2-BMP6-DSP-tel.

References

Dec 14, 1995·Nature·L Peltonen
Nov 1, 1995·Genome Research·M G OlavesenJ Ragoussis
Oct 25, 1996·Science·G D SchulerT J Hudson

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Citations

Oct 8, 2011·The Journal of Biological Chemistry·Jessica Finlay-SchultzSherry Leonard
Aug 28, 2012·Biochemistry Research International·Charles McCartanLyn R Griffiths
Jun 8, 1999·European Journal of Immunology·L Du PasquierI Chrétien
Mar 17, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ewa Moric-Janiszewska, Grazyna Markiewicz-Loskot

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