Fine-mapping of 98 obesity loci in Mexican children

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Hsin Yen LiuD Meyre

Abstract

Mexico has one of the highest prevalence of childhood obesity in the world. Genome-wide association studies (GWAS) for obesity have identified multiple single-nucleotide polymorphisms (SNPs) in populations of European, East Asian, and African descent. The contribution of these loci to obesity in Mexican children is unclear. We assessed the transferability of 98 obesity loci in Mexican children and fine-mapped the association signals. The study included 405 and 390 Mexican children with normal weight and obesity. Participants were genotyped with a genome-wide dense SNP array designed for Latino populations, allowing for the analysis of GWAS index SNPs as well as fine-mapping SNPs, totaling 750 SNPs covering 98 loci. Two genetic risk scores (GRS) were constructed: a "discovery GRS" and a "best-associated GRS", representing the number of effect alleles at the GWAS index SNPs and at the best-associated SNPs after fine-mapping for each subject. Seventeen obesity loci were significantly associated with obesity, and five had fine-mapping SNPs significantly better associated with obesity than their corresponding GWAS index SNPs in Mexican children. Six obesity-associated SNPs significantly departed from additive to dominant (N = 5) or ...Continue Reading

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Citations

May 10, 2019·Nature Reviews. Genetics·Vivian TamDavid Meyre
Nov 23, 2019·Genes·Paula Costa-UrrutiaMartha Eunice Rodríguez-Arellano
Dec 5, 2019·Annals of Human Genetics·Ángeles RamírezFernando Suárez-Sánchez
Dec 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Miguel Vázquez-MorenoDavid Meyre
Dec 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yuvreet KaurDavid Meyre
Apr 4, 2021·International Journal of Molecular Sciences·Augusto Anguita-RuizFrancisco Javier Ruiz-Ojeda
Jul 3, 2021·International Journal of Molecular Sciences·Caroline PhamElisabeth M Lodder

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Methods Mentioned

BETA
genotyping

Software Mentioned

R
SMARTPCA
PLINK
HuGE Navigator

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