Fine mapping of quantitative trait loci affecting female fertility in dairy cattle on BTA03 using a dense single-nucleotide polymorphism map.

Genetics
Tom DruetMathieu Gautier

Abstract

Fertility quantitative trait loci (QTL) are of high interest in dairy cattle since insemination failure has dramatically increased in some breeds such as Holstein. High-throughput SNP analysis and SNP microarrays give the opportunity to genotype many animals for hundreds SNPs per chromosome. In this study, due to these techniques a dense SNP marker map was used to fine map a QTL underlying nonreturn rate measured 90 days after artificial insemination previously detected with a low-density microsatellite marker map. A granddaughter design with 17 Holstein half-sib families (926 offspring) was genotyped for a set of 437 SNPs mapping to BTA3. Linkage analysis was performed by both regression and variance components analysis. An additional analysis combining both linkage analysis and linkage-disequilibrium information was applied. This method first estimated identity-by-descent probabilities among base haplotypes. These probabilities were then used to group the base haplotypes in different clusters. A QTL explaining 14% of the genetic variance was found with high significance (P < 0.001) at position 19 cM with the linkage analysis and four sires were estimated to be heterozygous (P < 0.05). Addition of linkage-disequilibrium inform...Continue Reading

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Citations

Aug 7, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Ming Fang
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·N C FriggensH V Petit
Mar 26, 2009·Bioinformatics·Jules Hernández-SánchezSara Knott
Oct 1, 2009·Genetics, Selection, Evolution : GSE·Andrés Legarra, Rohan L Fernando
Oct 26, 2010·Genetics, Selection, Evolution : GSE·Christine Cierco-AyrollesBrigitte Mangin
Dec 14, 2011·Genetics, Selection, Evolution : GSE·Mogens S LundGuosheng Su
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Jul 16, 2010·The Journal of Reproduction and Development·Anne BarbatPatrice Humblot
Jun 19, 2014·Veterinary Research·Guillaume SalléPhilippe Jacquiet
Jul 16, 2014·Genetics, Selection, Evolution : GSE·Laval JacquinHélène Gilbert
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Nov 25, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·S Coyral-CastelJ Dupont
Aug 16, 2011·Journal of Animal Science·S TeyssèdreA Ricard

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