Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma

International Journal of Cancer. Journal International Du Cancer
Hong Lok LungMaria Li Lung

Abstract

Previous studies transferring an intact chromosome 11 into HONE1 cells demonstrated the functional significance of chromosome regions, 11q13 and 11q22-23, in nasopharyngeal carcinoma (NPC) development. In our study the 11q22-23 region was comprehensively re-investigated by detailed microsatellite and single nucleotide polymorphism genotyping and by fluorescence in situ hybridization to map precisely the regions containing tumor suppressive activity. We observed 3 chromosomal intervals within 11q22-23 that were commonly lost in the tumor segregants derived from HONE1/chromosome 11 hybrids. One critical region of 0.36 Mb was mapped near the marker D11S2000 and a second 0.44 Mb region was located around the markers D11S1300 and D11S1391. In a third region high allelic loss was also observed at marker D11S4484, where a newly cloned tumor suppressor gene, TSLC1 (tumor suppressor in lung cancer 1), is located. The gene expression analysis showed absence or low expression levels of TSLC1 mRNA in 4 highly tumorigenic NPC cell lines. In addition, the methylation study results show that the TSLC1 promoter region was hypermethylated in all 4 NPC cell lines and re-expression of the gene occurs in HONE1 cells after 5-aza-2'-deoxycytidine tr...Continue Reading

Citations

Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Arthur Kwok Leung CheungMaria Li Lung
Mar 29, 2011·Chinese Journal of Cancer·Li-Li LiQian Tao
Feb 19, 2011·Cancer Investigation·Qi-Lian LiangBi-Rong Wang
Dec 14, 2011·Seminars in Cancer Biology·Hong Lok LungMaria Li Lung
Aug 13, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annemarie ZieglerBernd Wollscheid
Aug 25, 2006·International Journal of Cancer. Journal International Du Cancer·Wing Lung YauMaria Li Lung
Mar 21, 2012·Cancer Science·Shinji KikuchiYoshinori Murakami
Dec 18, 2010·International Journal of Cancer. Journal International Du Cancer·King Chi ChanMaria Li Lung
Nov 19, 2009·International Journal of Cancer. Journal International Du Cancer·Hong Lok LungMaria Li Lung
Jul 4, 2006·Biochemical and Biophysical Research Communications·Kyoko ShimizuToshifumi Tsujiuchi
May 5, 2007·Expert Reviews in Molecular Medicine·Qian Tao, Anthony T C Chan
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jin-Ching LinGuang-Jer Wu
Mar 13, 2018·Frontiers in Oncology·Kathrin OehlEmanuela Felley-Bosco
Jul 2, 2021·Biomarker Research·Edmund Ui-Hang SimKumaran Narayanan

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