PMID: 8613143Jan 1, 1996Paper

Fine mapping of the human pentraxin gene region on chromosome 1q23

Immunogenetics
M T WalshA S Whitehead

Abstract

The 1q21 to 25 region of human chromosome 1 contains genes which encode proteins with immune- and inflammation-associated functions. These include the pentraxin genes, for C-reactive protein (CRP), serum amyloid P (SAP) protein (APCS),a nd a CRP pseudogene (CRPP1). The region of chromosome 1 containing this cluster is syntenic with distal mouse chromosome 1. We constructed an approximately 1.4 megabase yeast artificial chromosome (YAC) contig with the pentraxin genes at its core. This four-YAC contig includes other genes with immune functions including the FCER1A gene, which encodes the alpha-subunit of the IgE high-affinity Fc receptor and the IFI-16 gene, an interferon-gamma-induced gene. In addition, it contains the histone H3F2 and H4F2 genes and the gene for erythroid alpha-spectrin (SPTA1). The gene order is cen.-SPTA1-H4F2-H3F2-IFI-16-CRP-CRPP1-APCS -FCER1A- tel. The contig thus consists of a cluster of genes whose products either have immunological importance, bind DNA, or both.

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Citations

Jun 17, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T MölkänenA Järvinen
Apr 19, 2005·Journal of Neuroimmunology·Nina M van SorgeLeonard H van den Berg
Dec 17, 2008·Genes, Brain, and Behavior·P SuchankovaA Ekman
Dec 25, 2009·Circulation. Cardiovascular Genetics·Renate B SchnabelEmelia J Benjamin
Feb 26, 2014·Psychiatry Research·Bisu Singh, Tapas Kumar Chaudhuri
Sep 18, 2007·Journal of the American College of Cardiology·Fadi G Hage, Alexander J Szalai
Sep 19, 2006·Biochimica Et Biophysica Acta·Janice E DrewLawrence N Barrera

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