Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese

Human Molecular Genetics
Meng ZhuZhibin Hu

Abstract

Several genome-wide association studies (GWAS) have demonstrated the association between genetic variants in the major histocompatibility complex (MHC) region and chronic hepatitis B (CHB) virus infection, but it is still unknown about the disease-causing loci and potential mechanisms owing to the complicated linkage disequilibrium for this region. To systematically characterize the MHC variations in relation to the CHB infection, we fine mapped the MHC region on our existing GWAS data with SNP2HLA taken the Pan-Asian panel as reference and finally identified four independent associations. The HLA-DPβ1 amino acid positions 84-87, which drove the effect of reported single nucleotide polymorphisms rs9277535 and rs3077, showed the most significant association (OR = 0.65, P = 2.03 × 10(-8)). The Leu-15 of HLA-C, conferring the effect of rs3130542, increased the risk of CHB infection independently (OR = 1.61, P = 3.42 × 10(-7)). The HLA-DRβ1*13, in perfect LD with glutamic at site 71, and rs400488, an expression quantitative trait locus for HLA-J, were newly identified to be associated with CHB infection independently (OR = 1.84, P = 3.84 × 10(-9); OR = 0.28, P = 6.27 × 10(-7), respectively). HLA-DPβ1 positions 84-87 and HLA-DRβ1 po...Continue Reading

References

Apr 17, 2002·Molecular Immunology·Jia-huai Wang, Ellis L Reinherz
Aug 29, 2006·World Journal of Gastroenterology : WJG·Ying-Li HeShu-Mei Lin
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Amitis RamezaniAli Akbar Velayati
Feb 17, 2009·Lancet·Yun-Fan Liaw, Chia-Ming Chu
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lingmin HuZhibin Hu
Jun 21, 2012·Genetic Epidemiology·Sang Hong LeePeter M Visscher
Nov 6, 2012·Biotechnology and Bioengineering·Lars KoberJuergen Bode
Jun 14, 2013·PloS One·Xiaoming JiaPaul I W de Bakker
Oct 29, 2013·Nature Genetics·Zhibin HuHongbing Shen
Dec 5, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Lin ChengGuohong Deng
Apr 5, 2014·Human Molecular Genetics·Nisha Esakimuthu PillaiYik-Ying Teo
Oct 4, 2014·American Journal of Human Genetics·Christine F SkibolaNathaniel Rothman
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 22, 2015·Nature Genetics·Javier Gutierrez-AchuryPaul I W de Bakker

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Citations

Jun 1, 2016·Journal of Immunology Research·Li WangKai Wang
Jan 24, 2017·Human Immunology·Matt J NevilleJulian C Knight
Sep 30, 2018·Journal of Viral Hepatitis·Guojin OuZhong Liu
Apr 30, 2017·Genome Biology·Vasiliki MatzarakiAlexandra Zhernakova
Sep 3, 2019·Frontiers in Genetics·Zhenhua ZhangMengji Lu
Dec 29, 2017·European Journal of Medical Research·Bing QiuLixin Tang
Aug 21, 2018·World Journal of Gastroenterology : WJG·Izzet Mehmet AkcayLevent Doganay
Dec 6, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jinghang XuZheng Zeng
Mar 13, 2021·Immunogenetics·Guojin OuJue Wang
Apr 10, 2021·Medicine·Guojin OuYongmei Jiang

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