Fine-needle aspiration biopsy allows early detection of acute rejection in children after renal transplantation

Transplantation
Maria TheirHannu Jalanko

Abstract

analysis detected rejections often before clinical signs. Half of the patients had increased serum creatinine concentration and 38% had fever at the time of rejection diagnosis. Both signs were present in only 19% of the episodes. A decrease in urine output (>20%) was seen in a third of the episodes. The rejections responded well to oral methylprednisolone (3 mg/kg/day), and lymphoglobulins were needed in only 12% of the episodes. More than 90% of the rejections were completely reversible and no transplant was lost because of acute rejection. The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow-up of acute cellular rejection in pediatric recipients of different ages.

References

Mar 1, 1991·Transplantation·S O BohmanP Häyry
May 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T E BunchmanS M Mauer
Sep 1, 1988·Kidney International·J H HeldermanA R Hull
Nov 1, 1980·Clinical Immunology and Immunopathology·E von Willebrand
May 1, 1993·Transplantation·G P BasadonnaJ S Najarian
Nov 10, 1998·Journal of the American Society of Nephrology : JASN·D RushJ Jeffery
Apr 30, 1999·Transplantation·E QvistC Holmberg

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Citations

Jun 28, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hannu JalankoChrister Holmberg
May 10, 2002·Pediatric Transplantation·Maria TheirHannu Jalanko
Apr 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohamad El-FaramawiBente Jespersen
May 2, 2001·Transplantation·P Belitsky, R Gupta

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