PMID: 11933272Apr 5, 2002Paper

Fine-needle aspiration biopsy in diagnosis of follicular lymphoma: cytomorphologic and immunohistochemical analysis

Diagnostic Cytopathology
Uma Nahar SaikiaAshim Das

Abstract

Follicular lymphoma is a relatively uncommon type of non-Hodgkin's lymphoma (NHL) thought to derive from follicular center cells. There are limitations to fine-needle aspiration in the diagnosis of follicular NHL, and very few studies are available on it. We describe here the cytomorphologic features of eight biopsy-proven cases of follicular NHLs and five biopsy-proven cases of intermediate-grade NHLs. Five cases of reactive lymphoid hyperplasia (RLH) diagnosed on cytology were also studied cytomorphologically. Image morphometry was done in follicular and intermediate-grade NHLs, immunocytochemistry was done in follicular and intermediate-grade NHLs, and immunocytochemistry for bcl-2 expression was studied in five cases of follicular NHLs. The aspirate smears of follicular NHL showed the presence of higher grades, many to abundant (++ to +++) monomorphic lymphoid aggregates, with an increased number of mast cells. Lymphohistiocytic tangles and tingeable body macrophages were not observed in any of the cases. Cytomorphologically, all the cases of intermediate-grade NHL showed a predominantly monomorphic population of lymphoid cells with absent or few grades (+) of lymphoid aggregates. Image morphometric data analysis of each ce...Continue Reading

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Citations

Jul 2, 2003·Journal of the American College of Surgeons·Leonidas G KoniarisRabih Salloum
Jun 14, 2012·Pathology Research International·Joerg Schwock, William R Geddie
Jan 4, 2012·British Journal of Haematology·Christopher McNamaraUNKNOWN British Society for Haematology Committee
Jun 25, 2020·British Journal of Haematology·Christopher McNamaraPam McKay
Nov 22, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jin Young KwakKi Whang Kim

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