PMID: 9664181Jul 17, 1998Paper

Fine-needle aspiration cytology in a case of isolated involvement of thyroid with Langerhans cell histiocytosis

Diagnostic Cytopathology
M SahooC S Bal

Abstract

We present an unusual case of isolated thyroid involvement with Langerhans cell histiocytosis (LCH), diagnosed presumptively by fine-needle aspiration (FNA) cytology and subsequently confirmed by immunohistochemistry in a 13-yr-old boy. The cytologic findings include high cellularity in a hemorrhagic background, the presence of characteristic mononucleated and multinucleated Langerhans cells with prominent nuclear grooves, and abundant foamy cytoplasm in a background of mixed eosinophilic and aggregates of benign thyroid follicular cells. Further diagnostic confirmation was obtained by positive S-100 protein immunohistochemistry of the Langerhans histiocytes on paraffin-embedded sections of open thyroid biopsy of the prominently enlarged left lobe. We present the complete clinicopathologic features of this case, along with ultrasound, computerized axial tomographic, and technetium-99 scan findings. We also discuss possible differential diagnostic consideration in light of a review of the literature and the role of FNA cytologic diagnosis in such a rare yet cytomorphologically characteristic case.

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Citations

Apr 5, 2011·International Journal of Endocrinology·Ramon VilallongaMari Carmen Ruiz Marcellán
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Veysel Nijat BaşZehra Aycan
Aug 4, 2001·Thyroid : Official Journal of the American Thyroid Association·R J BehrensD S Cooper
Oct 4, 2005·Annals of Diagnostic Pathology·Danielle D ElliottL Jeffrey Medeiros
Apr 1, 2008·Indian Journal of Pediatrics·Urmila N KhadilkarMukta R Pai
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·W M YapP H Tan
Apr 20, 2007·European Journal of Pediatrics·Begül YağciMünevver Büyükpamukçu
Dec 27, 2011·Head and Neck Pathology·Darren K PattenNeil Tolley
Jan 19, 2015·Head and Neck Pathology·Anjali SaqiTamar A Giorgadze

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