PMID: 9557261Apr 29, 1998Paper

Fine-needle aspiration cytology of amyloid associated with nonneoplastic and malignant lesions

Diagnostic Cytopathology
B E HallidayJ L Finley

Abstract

To assess the value of fine-needle aspiration (FNA) cytology for the diagnosis of amyloid, we retrospectively studied all FNA cases diagnosed as having amyloid during a 6-yr period (1990-1996). FNA was performed on both superficial and deep locations. A total of 6 cases containing amyloid was studied, including primary medullary thyroid carcinoma, metastatic medullary thyroid carcinoma to a vertebrae, multiple myeloma, squamous-cell carcinoma of the lung metastatic to a hilar lymph node, primary pulmonary amyloid, and amyloid tumor in a vertebral body in a patient with primary systemic amyloidosis. Despite the location or disease association, the cytologic appearance of amyloid in all cases was similar. On Diff-Quik stain, amyloid appeared as amorphous, irregular, waxy basophilic to metachromatic clumps of material. Papanicolaou stain revealed cyanophilic to organophilic clumps of material with occasional prominent fissures. In all 6 cases, amyloid was confirmed by Congo red stain and in 3 cases by a thioflavin T stain. In 4 of the 6 cases (67%), amyloid was associated with an underlying malignancy. In 3 cases malignant cells were admixed with the amyloid, and in another case malignancy was present at a distant site. We conclud...Continue Reading

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Citations

Nov 15, 2011·Diagnostic Cytopathology·Prakash H MuddeGowdaRamkumar Kurpad
Mar 1, 2012·Diagnostic Cytopathology·Camille T ElkinsPaul E Wakely
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David Z ChangCarol S Portlock
Feb 22, 2017·Diagnostic Cytopathology·Hannah H ChenEva M Wojcik
Jul 6, 2004·Diagnostic Cytopathology·Tamar GiorgadzePrabodh K Gupta
May 28, 2003·Diagnostic Cytopathology·Sunati SahooRichard M DeMay
Nov 26, 2019·Diagnostic Cytopathology·Garima RakhejaSarabmeet S Lehl
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