PMID: 11933267Apr 5, 2002Paper

Fine-needle aspiration cytology of phyllodes tumors

Diagnostic Cytopathology
Gita Jayaram, Pavai Sthaneshwar

Abstract

Breast lesions with a significant spindle cell or mesenchymal component are not commonly encountered in fine-needle aspiration (FNA) cytologic material and include a heterologous variety of benign and malignant conditions, with phyllodes tumors (PTs) being the foremost differential diagnostic consideration. This study comprises 28 tumors diagnosed histologically as PT in which FNAC material was available for review. Histological sections and cytological smears from these cases were retrieved and subjected to detailed morphological review. Cytological parameters assessed included ratio of stroma to epithelium, pattern characteristics and cytological characteristics of the stromal, and epithelial components and the background cells. Large and hypercellular stroma fragments, dissociated spindle and plump stromal cells, often accompanied by large, folded sheets of epithelium were cytological features that characterized PT. Smears from malignant PT showed predominantly or solely mesenchymal components. FNAC was a highly reliable procedure for the diagnosis of PT, giving an accuracy rate of 92.8%.

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Citations

Jun 8, 2010·Breast Cancer Research and Treatment·Gary M Tse, Puay-Hoon Tan
Feb 8, 2006·Journal of Clinical Pathology·R K JacklinA Darzi
Jun 27, 2006·Journal of Clinical Pathology·Philip C W LuiAye T Khin
Nov 16, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshito TomimaruHiroki Koyama
Dec 16, 2010·Journal of Cytology·Ranjana BandyopadhyaySwapan Kumar Sinha
Apr 12, 2013·ISRN Surgery·Shashi Prakash MishraAjay Kumar Khanna
Nov 7, 2006·Surgery·Mary F DillonArnold D K Hill
Nov 21, 2008·Diagnostic Cytopathology·Regina Van Buren, Jimmie Stewart
May 28, 2014·Diagnostic Cytopathology·Takahiko SakumaKouichiro Tagami
Jul 25, 2006·American Journal of Surgery·Jamel Ben HassounaKhaled Rahal
Aug 1, 2006·The Breast : Official Journal of the European Society of Mastology·L M FoxcroftA J Porter
Mar 5, 2019·Diagnostic Cytopathology·Joshua J X LiGary M Tse
Apr 12, 2019·Diagnostic Cytopathology·Jitendra Singh NigamShibojit Talukder
Jan 23, 2010·Cancer Cytopathology·Imad A El HagH Al-Hussaini
Jul 15, 2020·BMC Cancer·Santosh TummidiPrashant Sood
May 7, 2009·Archives of Pathology & Laboratory Medicine·Dilip Giri

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