PMID: 11335963May 4, 2001Paper

Fine-needle aspiration cytology of postvaccinial disseminated bacillus Calmette-Guerin infection

Diagnostic Cytopathology
L A Al-Bhlal

Abstract

Nine patients with primary immunodeficiency who received bacillus Calmette-Guerin (BCG) vaccine at birth developed disseminated BCG lesions and presented clinically with generalized skin rash and skin nodules. Fine-needle aspiration biopsy of the skin nodules and/or enlarged lymph nodes was performed in all patients. The most common cytologic pattern encountered was cellular smears showing a large number of histiocytes with abundant streaked cytoplasm in a background of neutrophils and debris. No granulomas were noted. Ziehl-Neelsen (ZN) stain for acid-fast bacilli showed a large number of these bacilli within the cytoplasm of the histiocytes, and extracellularly. This pattern was seen in 6 patients. The cytologic smears from 3 patients showed epithelioid granulomas in a background of neutrophils and debris. ZN stain for acid-fast bacilli showed fewer numbers of these bacilli compared to the first cytologic pattern. In conclusion, the most common cytologic pattern of postvaccinial disseminated BCG lesions in immunocompromised patients is a large number of histiocytes with abundant streaked cytoplasm in a background of neutrophils and debris. No epithelioid granulomas are seen in this pattern. A less frequent pattern is also enc...Continue Reading

References

Jun 21, 1980·Lancet·J R Guarino
Dec 20, 1980·Lancet·A MackayR G White
Jul 1, 1993·American Journal of Clinical Pathology·C AbramowskyR U Sorensen
Mar 1, 1997·Acta Cytologica·K GuptaB Singh

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Citations

Feb 3, 2004·Diagnostic Cytopathology·S HwangA L Moreira
Sep 13, 2012·Virchows Archiv : an International Journal of Pathology·Snjezana DotlicStefan D Dojcinov

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