Fine needle aspiration cytology of dedifferentiated acinic cell carcinoma of the parotid gland: a case report

Acta Cytologica
Pilar González-PeramatoJ M Viguer

Abstract

Dedifferentiation of acinic cell carcinoma (ACC) to undifferentiated carcinoma occurs rarely and entails a poor prognosis. Most cases of dedifferentiation occur as recurrences of a previously excised ACC. More rarely the neoplasm presents with areas of well-differentiated ACC coexisting with dedifferentiated ones. An 85-year-old man presented with 2 nodular areas in the right parotid area. Fine needle aspiration of both nodules was performed. In both cases cytology revealed a double epithelial component in similar proportions. The first one corresponded to cohesive groups of small to intermediate-sized, polygonal cells with round, monomorphic nuclei. They were distributed in small and larger, branching groups with acinic morphology. Intermixed with this population, irregular groups of larger, pleomorphic cells with irregular nuclei, prominent nucleoli and scarce cytoplasm were present. In addition, smears showed an abundant lymphoid background. A cytologic diagnosis of "salivary carcinoma with coexisting areas of acinic cell differentiation and high grade, undifferentiated carcinoma" was given. Histopathology revealed a well-differentiated ACC with areas of high grade undifferentiated carcinoma (dedifferentiated ACC). The curre...Continue Reading

Citations

Jul 4, 2013·Head and Neck Pathology·Toshitaka Nagao
Aug 31, 2011·Pathology Research International·Ana Flávia CostaMario Hermsen
Feb 28, 2014·Diagnostic Cytopathology·Akiko KagotaniHidetoshi Okabe
Jan 24, 2015·Diagnostic Cytopathology·Ruchita Tyagi, Pranab Dey
Sep 11, 2020·Head and Neck Pathology·Kristine S WongVickie Y Jo
Aug 12, 2021·Cancer Cytopathology·Paul E Wakely, Abberly A Lott-Limbach

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