PMID: 9557258Apr 29, 1998Paper

Fine-needle aspiration of Merkel cell carcinoma of the skin with cytomorphology and immunocytochemical correlation

Diagnostic Cytopathology
B T CollinsR R Ramos

Abstract

Merkel cell carcinoma (MCC) of the skin is a rare, primary malignant skin neoplasm which can present as a cutaneous nodule. These neoplasms are seen primarily in the elderly and located in the head and neck area or extremities. Twenty-nine aspirates from primary and metastatic lesions obtained by percutaneous fine-needle aspiration in 19 patients have been studied. The cytomorphologic features, clinical information, and immunocytochemical (ICC) findings are detailed. Aspirate smears demonstrated small-to-intermediate-sized cells with a loosely cohesive pattern. Nuclei were round with finely granular chromatin and multiple, small nucleoli. Cells possessed a thin rim of cytoplasm, and infrequent pseudorosette formations were noted in cell groups. ICC results were universally positive for cytokeratin, which showed a paranuclear "dot-like" pattern. Neuron-specific enolase, epithelial membrane antigen, and S-100 protein were positive in varying degrees. Leukocyte common antigen was universally negative. The diagnosis of MCC of the skin by FNA can be made by applying cytologic features in addition to ancillary studies and clinical information.

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Citations

Mar 12, 2013·Journal of Skin Cancer·Elisabeth EnzenhoferBoban M Erovic
Dec 12, 2012·Cancer Cytopathology·Charles J BechertRanjana Nawgiri
Apr 8, 2010·Current Problems in Cancer·Timothy W McCardleJane L Messina
May 15, 2009·The British Journal of Dermatology·E Güler-NizamT K Eigentler
Dec 7, 2011·Diagnostic Cytopathology·Stewart M KnoeppMichael H Roh
Aug 17, 2001·Cancer·M M LemosH Willén
Jul 31, 2001·Diagnostic Cytopathology·A C HenkeT G Timmerman
Dec 5, 1998·Diagnostic Cytopathology·J F Legier
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfram GoesslingRobert J Mayer

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