Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature.

Cancer Cytopathology
Masato NakaguroPeter M Sadow

Abstract

High-grade transformation (HGT) is a rare process whereby conventional low- to intermediate-grade salivary gland carcinomas (SGC) transform into high-grade, poorly or undifferentiated malignancies with focal or complete loss of their conventional histomorphologic features. Because tumors with HGT are associated with a worse prognosis than their conventional counterparts, preoperative recognition of HGT may be of benefit for optimal patient management. Using a multi-institutional approach, we describe the largest fine needle aspiration (FNA) cohort of salivary gland carcinomas with HGT. The archives of 9 large academic medical centers were searched, and 22 cases of SGC with HGT were identified by surgical excision accompanied by preoperative FNA. Clinical and cytomorphologic features were retrospectively reviewed. The male-to-female ratio was 14:8, and the mean patient age was 60.2 years. The average tumor size was 3.6 cm, and 19 cases were from the parotid gland. Acinic cell carcinoma with HGT was the most common tumor subtype, comprising 12 cases with HGT, followed by adenoid cystic carcinoma, secretory carcinoma, and other subtypes. Eighteen cases were classified as malignant; however, a specific diagnosis of HGT was not made...Continue Reading

References

Nov 11, 2003·Human Pathology·Toshitaka NagaoJean E Lewis
Dec 7, 2007·The American Journal of Surgical Pathology·Raja R SeethalaE Leon Barnes
Aug 4, 2010·The American Journal of Surgical Pathology·Paromita RoyIlan Weinreb
Jul 4, 2013·Head and Neck Pathology·Toshitaka Nagao
Aug 5, 2014·Diagnostic Cytopathology·Min Jung JungKyung-Ja Cho
Jun 13, 2018·Journal of Cancer Research and Therapeutics·Minakshi Bhardwaj, Prajwala Gupta
Aug 30, 2018·Cancer Cytopathology·Vickie Y Jo, Jeffrey F Krane
May 23, 2019·BMC Cancer·Qigen FangXu Zhang
May 19, 2020·Cancer Cytopathology·Masato NakaguroToshitaka Nagao

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Citations

Aug 12, 2021·Cancer Cytopathology·Paul E Wakely, Abberly A Lott-Limbach

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