PMID: 20641029DOI: 10.1002/yea.1791Jul 20, 2010Paper
Fine regulation of Saccharomyces cerevisiae MAPK pathways by post-translational modifications
Yeast
María MolinaHumberto Martín
Abstract
Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen-activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine-tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post-transcriptional modifications on their components. The impact of recent phosphoproteomic approaches in this particular field is also discussed.
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