Fine-scale analysis of 16S rRNA sequences reveals a high level of taxonomic diversity among vaginal Atopobium spp

Pathogens and Disease
Helena Mendes-SoaresLarry J Forney

Abstract

Although vaginal microbial communities of some healthy women have high proportions of Atopobium vaginae, the genus Atopobium is more commonly associated with bacterial vaginosis, a syndrome associated with an increased risk of adverse pregnancy outcomes and the transmission of sexually transmitted diseases. Genetic differences within Atopobium species may explain why single species can be associated with both health and disease. We used 16S rRNA gene sequences from previously published studies to explore the taxonomic diversity of the genus Atopobium in vaginal microbial communities of healthy women. Although A. vaginae was the species most commonly found, we also observed three other Atopobium species in the vaginal microbiota, one of which, A. parvulum, was not previously known to reside in the human vagina. Furthermore, we found several potential novel species of the genus Atopobium and multiple phylogenetic clades of A. vaginae. The diversity of Atopobium found in our study, which focused only on samples from healthy women, is greater than previously recognized, suggesting that analysis of samples from women with BV would yield even more diversity. Classification of microbes only to the genus level may thus obfuscate differ...Continue Reading

References

Jan 11, 1992·International Journal of Systematic Bacteriology·G E FoxP Jurtshuk
Sep 1, 1990·Reviews of Infectious Diseases·V Redondo-LopezJ D Sobel
Dec 1, 1996·Infection and Immunity·H Ochman, E A Groisman
Nov 11, 1999·International Journal of Systematic Bacteriology·M Rodriguez JovitaE Falsen
Apr 1, 2000·Microbes and Infection·S L MarcusB B Finlay
Oct 6, 2000·Annual Review of Microbiology·J Hacker, J B Kaper
Nov 30, 2000·Current Infectious Disease Reports·J D Sobel
Mar 22, 2001·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T HayashiH Shinagawa
Jun 22, 2001·Microbes and Infection·E Carniel
Jun 22, 2001·Microbes and Infection·J A Vázquez-BolandW Goebel
Jun 5, 2002·Lancet·Tadashi BabaKeiichi Hiramatsu
Jun 22, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jon JonassonHans-Jürg Monstein
Apr 24, 2003·Journal of Dental Research·P S KumarE J Leys
Jun 7, 2003·Journal of Clinical Microbiology·Walter GeissdörferChristian Bogdan
Jul 18, 2003·Journal of Bacteriology·Ann Karen C BrassingaPaul S Hoffman
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Hans VerstraelenMario Vaneechoutte
Mar 18, 2006·BMC Infectious Diseases·Ellen De BackerMario Vaneechoutte
Jul 18, 2006·Nucleic Acids Research·T Z DeSantisG L Andersen
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Jun 3, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Pierre MenardDidier Raoult
Nov 14, 2008·Nucleic Acids Research·J R ColeJ M Tiedje
Feb 24, 2009·Journal of Pediatric and Adolescent Gynecology·Ted YamamotoLarry J Forney
Jun 17, 2009·Infection and Immunity·Xia ZhouLarry J Forney
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yoshitoshi OguraTetsuya Hayashi
Nov 17, 2009·FEMS Immunology and Medical Microbiology·Xia ZhouLarry J Forney
Nov 17, 2009·Bioinformatics·J Gregory CaporasoRob Knight
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacques RavelLarry J Forney

❮ Previous
Next ❯

Citations

Nov 26, 2015·Fertility and Sterility·Katherine A GreenWilliam H Catherino
Mar 31, 2017·Critical Reviews in Microbiology·Hyun-Sul JungMarleen M Kock
Aug 10, 2017·Journal of Medical Microbiology·Carolina Sanitá Tafner FerreiraCamila Marconi
Mar 19, 2020·Journal of Women's Health·Michelle Lynn Wright
Jun 30, 2018·Scientific Reports·Heidi TuominenJaana Rautava
Mar 4, 2021·Microbial Genomics·Brett A TortelliJustin C Fay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.