Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

PloS One
Pierre LuisiH. Dopazo

Abstract

Similarly to other populations across the Americas, Argentinean populations trace back their genetic ancestry into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to perform population structure analyses at a sub-continental level. Concerning the Native American ancestry, we could identify four Native American components segregating in modern Argentinean populations. Three of them are also found in modern South American populations and are specifically represented in Central Andes, Central Chile/Patagonia, and Subtropical and Tropical Forests geographic areas. The fourth component might be specific to the Central Western region of Argentina, and it is not well represented in any genomic data from the literature. As for the European and African ancestries, we confirmed previous...Continue Reading

References

Apr 20, 2001·Forensic Science International : Synergy·D CorachA Sala
Jun 1, 2001·American Journal of Physical Anthropology·A S GoicoecheaF M Salzano
Feb 12, 2004·American Journal of Human Genetics·Antonio SalasAngel Carracedo
Feb 17, 2005·American Journal of Physical Anthropology·Laura FejermanRyk H Ward
Dec 21, 2006·American Journal of Physical Anthropology·Michael F SeldinMarta E Alarcon-Riquelme
Dec 30, 2006·PLoS Genetics·Nick PattersonDavid Reich
Mar 29, 2008·PLoS Genetics·Sijia WangAndrés Ruiz-Linares
Jun 19, 2008·Journal of Human Genetics·A SalasÁ Carracedo
Sep 2, 2008·Nature·John NovembreCarlos D Bustamante
Aug 4, 2009·Genome Research·David H AlexanderKenneth Lange
Jan 12, 2010·Annals of Human Genetics·Daniel CorachManfred Kayser
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Katarzyna BrycCarlos D Bustamante
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Oct 12, 2010·Bioinformatics·Ani ManichaikulWei-Min Chen
Jun 10, 2011·Bioinformatics·Petr DanecekUNKNOWN 1000 Genomes Project Analysis Group
Dec 6, 2011·Nature Methods·Olivier DelaneauJean-François Zagury
Apr 17, 2012·PloS One·Sergio AvenaLaura Fejerman
Jun 26, 2012·American Journal of Human Genetics·Luca PaganiChris Tyler-Smith
Jul 18, 2012·Nature·David ReichAndrés Ruiz-Linares
Sep 11, 2012·Genetics·Nick PattersonDavid Reich
Nov 2, 2012·American Journal of Physical Anthropology·Angelina GarcíaDarío A Demarchi
Aug 6, 2013·American Journal of Human Genetics·Brian K MaplesCarlos D Bustamante
Nov 19, 2013·PLoS Genetics·Andrés Moreno-EstradaCarlos D Bustamante
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fernanda S G KehdyUNKNOWN Brazilian EPIGEN Project Consortium
Oct 4, 2015·Nature·UNKNOWN 1000 Genomes Project ConsortiumGonçalo R Abecasis
Oct 27, 2015·Genetics and Molecular Biology·Angelina GarcíaMara H Hutz
Dec 5, 2015·PLoS Genetics·Julian R HomburgerCarlos D Bustamante
Apr 4, 2017·American Journal of Human Genetics·Alicia R MartinEimear E Kenny
Nov 4, 2017·American Journal of Human Genetics·Cesar Fortes-LimaJean-Michel Dugoujon
Jan 31, 2018·Journal of Human Genetics·Angelina GarcíaDarío A Demarchi
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Constanza de la FuenteMauricio Moraga
May 2, 2018·PloS One·Marina MuzzioEimear E Kenny
May 8, 2018·Genome Research·Alberto Gómez-CarballaAntonio Salas
Nov 10, 2018·Science·J Víctor Moreno-MayarEske Willerslev
Nov 13, 2018·Science Advances·John LindoAnna Di Rienzo
Mar 22, 2019·Molecular Biology and Evolution·Guido Alberto Gnecchi-RusconeDavide Pettener
Jun 18, 2019·PloS One·María Laura ParolinLeonor Gusmão

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Citations

Dec 29, 2020·American Journal of Physical Anthropology·Jorge I MartínezJosé E Dipierri
Mar 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Sebastian Alexis VishnopolskaMaria Ines Pérez-Millán

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Methods Mentioned

BETA
genotyping
PCA
MDS

Software Mentioned

RFMIx
AS
Clovis
plink
Principal Analyses
shapeIT2
ASPCA
Admixture
lsqproject
Smartpca

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