Fine-specificity differences in the recognition of an encephalitogenic peptide by T helper 1 and 2 cells

Journal of Neuroimmunology
R C van der VeenJ L Trotter

Abstract

The lymphokine production of two T-cell clones, which both recognize epitopes within the encephalitogenic 139-151 sequence of myelin proteolipid protein, was examined after stimulation with immobilized antibodies to the CD3 moiety of the T-cell-receptor complex. Clone A1 produced interleukin (IL)-2 and interferon (IFN)-gamma, but no IL-4, while clone D5 produced IL-4, but no IL-2 or IFN-gamma. A1 therefore belongs to the T-helper type 1 (Th1) subset, while D5 is a Th2 clone. In addition, the Th1 clone induced severe experimental allergic encephalomyelitis (EAE), while the Th2 clone did not induce any signs of EAE. Synthetic peptides were used to demonstrate that these clones recognized slightly different epitopes within the 139-151 sequence. Histidine 139 was shown to be optimal for the stimulation of the Th2 clone, while the presence of this residue inhibited the stimulation of the Th1 clone. Th2 cells specific for an encephalitogenic peptide may be important in the regulation of encephalitogenic Th1 cells.

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Citations

Sep 1, 1995·Journal of Neuroimmunology·B KalmanF D Lublin
Dec 1, 1995·Current Opinion in Immunology·B Charlton, K J Lafferty
Sep 1, 1994·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Olsson
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Nov 21, 2007·Journal of Neuroimmunology·Ioana R MoldovanClara M Pelfrey
Jun 24, 2008·Annals of the New York Academy of Sciences·Bianca M Conti-FineWei Wang
Apr 13, 2013·Journal of the Neurological Sciences·Abdolmohamad Rostami, Bogoljub Ciric
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Jul 3, 2002·Current Treatment Options in Cardiovascular Medicine·Anita Saxena
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P I KarachunskiB M Conti-Fine
May 29, 1998·European Journal of Immunology·M TakeuchiO Taguchi

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