PMID: 6166702Mar 1, 1981Paper

Fine specificity of genetic regulation of guinea pig T lymphocyte responses to angiotensin II and related peptides

The Journal of Experimental Medicine
D W ThomasG D Wilner

Abstract

Guinea pig T lymphocyte responses to the octapeptide antigen angiotensin II (NH(2)-Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)-OH; AII) were examined using various synthetic peptide analogues and homologues. Each peptide antigen was assessed for immunogenicity and antigenicity in strain 2 and strain 13 guinea pigs as determined by in vitro T cell proliferative responses. The genetic control of T cell responses to these peptides was found to be highly specific and capable of distinguishing subtle differences in the antigens. For example, strain 2 guinea pigs responded to AII and were low responders to [Val(5)]-AII, whereas strain 13 animals responded to [Val(5)]-AII but not to AII. The genetic control in this case involved the difference of one methyl group between Val(5) and Ile(5). Differences in T cell responsiveness by strain 2 and strain 13 guinea pigs were also observed with analogues involving para substitutions on the phenyl ring of Tyr(4) and of Phe(8). However, the genetic regulation of T cell responses did not seem to be based on a single peptide residue. For example, removal of Asp(1) allowed strain 13 animals to respond to the Ile(5)-containing analogue, but eliminated responsiveness to the Val(5)-contai...Continue Reading

References

Jan 1, 1966·International Archives of Allergy and Applied Immunology·F M Dietrich

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Jan 1, 1994·Molecular Immunology·Y AltuviaH Margalit
Jan 1, 1987·Immunology Today·O Werdelin
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·I BerkowerJ A Berzofsky
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E C DeFreitasH Koprowski
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D EckelsJ R Lamb
Jul 1, 1982·The Journal of Experimental Medicine·D W ThomasG D Wilner
Aug 1, 1987·Immunological Reviews·S BuusH M Grey
Oct 1, 1982·Allergy·O Werdelin
Feb 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·S Buus, O Werdelin

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