PMID: 3758495Nov 1, 1986Paper

Fine structural abnormalities of the placenta in diabetic rats

Diabetes
I H GewolbA C Enders

Abstract

In the streptozocin-induced diabetic rat, the placenta is larger and the fetus is smaller than normal. To study cellular differences that might contribute to the size and functional disparity between diabetic and control placentas, a light- and electron-microscopic analysis was performed on 14-, 18-, and 22-day (term) control and diabetic placentas. Diabetic placentas, especially later in gestation, were marked by the presence of large numbers of glycogen-distended cells in the basal zone. Within the placental labyrinth, the trophoblastic layers of the interhemal membrane were significantly thicker in the diabetic placentas on days 18 and 22, and large accumulations of liid droplets were present, especially in the inner two trophoblastic layers. In normal placentas there is a marked thinning of the placental barrier in the labyrinth by day 22 of gestation, making the thickness of the labyrinthine layers in age-matched diabetic placentas even more impressive. Finally, the labyrinth of 22-day diabetic placentas contained more glycogen and rough endoplasmic reticulum in the inner trophoblastic layer, a feature that is found in less-mature (18-day) control placentas. Thus, the diabetic placentas have a number of features that are c...Continue Reading

Citations

Jul 1, 1988·Journal of Steroid Biochemistry·C L HellerA F De Nicola
Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jan 9, 2001·Early Human Development·S M HusainZ M Mughal
Jul 1, 1987·The Journal of Clinical Investigation·J F SissomJ B Warshaw
Jul 1, 1995·The Journal of Clinical Investigation·P BoileauS Hauguel-de Mouzon
Feb 5, 2014·Endocrine·Priscilla S FariasMarlúcia B Aires
Feb 1, 1996·Pathology International·B YounesZ Abu Talib
Dec 11, 2007·Journal of Anatomy·F R C GiachiniS San Martin
Jul 16, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M B AiresD A Maria
Jul 1, 2020·BMJ Open Diabetes Research & Care·Jackson NteebaMichael J Soares
Mar 15, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·R PadmanabhanM A Ayoub
Feb 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ryuta IshimuraChiharu Tohyama
May 20, 2008·Archives of Physiology and Biochemistry·Yang YuReinald Fundele
Apr 1, 1988·The American Journal of Physiology·J VerhaegheR Bouillon
Oct 3, 1998·American Journal of Obstetrics and Gynecology·H ForsbergU J Eriksson
Nov 26, 2008·Biochemical Pharmacology·Ryuta IshimuraChiharu Tohyama

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