PMID: 13549502May 25, 1958Paper

Fine structure of changes produced in cultured cells sampled at specified intervals during a single growth cycle of polio virus

The Journal of Biophysical and Biochemical Cytology
F KALLMANM VOGT

Abstract

Primary suspended cultures of rhesus monkey kidney cells were infected with poliomyelitis virus, type 1 (Brunhilde strain). The release of virus from these cells over a one-step growth curve was correlated with their change in fine structure, as seen in the electron microscope. Most of the cells were infected nearly simultaneously, and morphological changes developed in the cells were sufficiently synchronous to be classified into three stages. The earliest change (stage I) became visible at a time when virus release into the culture fluid begins, some 3 hours after adsorption. Accentuation of the abnormal characteristics soon occurs, at 4 to 7 hours after adsorption, and results in stage II. Stage III represents the appearance of cells after their rate of virus release had passed its maximum, and probably the abnormal morphology of these cells reflects non-specific physiological damage. There seems to be consistency between the previously described cellular changes as seen under the light microscope and the finer scale changes reported here. Cytoplasmic bodies, called U bodies, were seen in large number at the time when the virus release was the most rapid (stage II). While these bodies are not of proper size to be considered ...Continue Reading

References

Sep 27, 1955·Annals of the New York Academy of Sciences·R DULBECCO, M VOGT
Sep 27, 1955·Annals of the New York Academy of Sciences·A LWOFFM LWOFF
Sep 1, 1956·The Journal of Experimental Medicine·D W HOWESM REISSIG
May 25, 1957·The Journal of Biophysical and Biochemical Cytology·S L CLARK
Nov 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·F C ROBBINST H WELLER

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Citations

Jan 1, 1960·Zeitschrift für Zellforschung und mikroskopische Anatomie·D DUNCAN, W HILD
Dec 11, 2013·Journal of Cardiovascular Translational Research·Andreas KoenigIwona A Buskiewicz
Nov 1, 1961·The Journal of Biophysical and Biochemical Cytology·O NUNEZ-MONTIELJ VITELLI-FLORES
Nov 1, 1973·The Journal of Cell Biology·L D Heding, D A Wolff
Dec 1, 1959·The Journal of Biophysical and Biochemical Cytology·F KALLMAND T IMAGAWA
Sep 1, 1960·The Journal of Biophysical and Biochemical Cytology·O NUNEZ-MONTIEL, J WEIBEL
Dec 1, 1960·The Journal of Biophysical and Biochemical Cytology·E NELSONE KOVACS
Jul 1, 1961·The Journal of Experimental Medicine·R A RIFKINDH M ROSE
May 1, 1971·Japanese Journal of Microbiology·R Kawana, I Matsumoto
Nov 11, 2011·Journal of Virology·George A BelovEllie Ehrenfeld
Nov 22, 2008·PLoS Pathogens·George A BelovEllie Ehrenfeld
Oct 14, 2011·Viruses·Kathryn A Klein, William T Jackson
Jul 24, 2014·Viruses·Inés Romero-Brey, Ralf Bartenschlager
Mar 30, 2016·Trends in Microbiology·Hilde M van der SchaarFrank J M van Kuppeveld
Jul 1, 1965·Virology·S DALESG E PALADE
Mar 10, 2015·Virology·Christian Harak, Volker Lohmann
Sep 23, 2014·Current Opinion in Virology·George A Belov
Jun 25, 2016·Viruses·Inés Romero-Brey, Ralf Bartenschlager
Oct 1, 1959·Experimental Cell Research·D C STUART, J FOGH
Jun 13, 2014·Journal of Virology·George A Belov, Elizabeth Sztul
Jul 21, 1959·Annals of the New York Academy of Sciences·C G HARFORDE P RODERMUND
Jul 21, 1959·Annals of the New York Academy of Sciences·R LOVE
Sep 26, 2020·Frontiers in Microbiology·Xinhong LiXiaoyue Chen
Feb 8, 1963·Science·E NelsonE Kovács

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