PMID: 5901500Jan 1, 1966

Fine structure of desmosomes. , hemidesmosomes, and an adepidermal globular layer in developing newt epidermis

The Journal of Cell Biology
D E Kelly

Abstract

The skin of late embryonic, larval, and young postmetamorphic newts, Taricha torosa, has been examined with particular reference to areas of cellular attachment. Stereo electron microscopic techniques and special staining methods for extracellular materials were utilized in addition to conventional avenues of ultrastructural study to investigate the fine architecture of desmosomes, hemidesmosomes, their associated filament systems, and extracellular materials. No evidence has been found that continuity of tonofilaments between adjacent cells exists at desmosomes. Rather, most of the tonofilaments which approach desmosomes (and perhaps also hemidesmosomes) course toward the "attachment plaque" and then loop, either outside the plaque or within it, and return into the main filament tracts of the cell. These facts suggest that the filamentous framework provides intracellular tensile support while adhesion is a product of extracellular materials which accumulate at attachment sites. Evidence is presented that the extracellular material is arranged as pillars or partitions which are continuous with or layered upon the outer unit cell membrane leaflets and adjoined in a discontinuous dense midline of the desmosome. A similar analysis...Continue Reading

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