Fine structure of hepatocytes from fasted and fed rats.

The American Journal of Anatomy
M B Babcock, R R Cardell

Abstract

The fine structure of hepatocytes from rats maintained on a controlled feeding schedule are described. Liver samples were processed for electron microscopy, histochemistry and chemical determinations of glycogen at precise time-intervals following a 30-hour fast and a 2-hour meal. Hepatocytes from 30-hour-fasted rats with extremely low hepatic glycogen levels were devoid of glycogen particles. Centrilobular cells showed areas of the cytoplasm rich in vesicles of smooth endoplasmic reticulum (SER) while periportal hepatocytes contained less extensive regions of SER. Soon after feeding the fasted rats, glycogen particles appeared in regions of the cell rich in SER. Centrilobular hepatocytes contained numerous glycogen areas which were infiltrated with tubules of SER, while periportal cells showed dense glycogen deposits with SER restricted to the periphery of the masses of glycogen. Throughout glycogen deposition each glycogen particle was closely associated with membranes of SER until maximum glycogen deposition was achieved 12 hours after initiation of feeding. At this point SER was reduced to the lowest amounts of the time-periods studied. During stages of glycogen depletion SER proliferated and reached the highest concentrati...Continue Reading

References

Jan 1, 1968·The American Journal of Anatomy·B Corrin, K Aterman
Jul 1, 1974·The American Journal of Anatomy·M B Babcock, R R Cardell
Mar 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A L Jones, D W Fawcett
Feb 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C de Man, A P Blok
Jul 1, 1952·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·W EGER, H OTTENSMEIER
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Dec 1, 1960·The Journal of Biophysical and Biochemical Cytology·J P REVELD W FAWCETT
Jun 1, 1961·The Journal of Biophysical and Biochemical Cytology·D J LUCK
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Sep 1, 1961·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J H KUGLER, W J WILKINSON
Jul 1, 1948·Stain Technology·J F A McMANUS
Dec 1, 1962·The Journal of Cell Biology·A V Loud
Nov 1, 1946·Proceedings of the Society for Experimental Biology and Medicine·H W DEANEA B HASTINGS

❮ Previous
Next ❯

Citations

Sep 1, 1978·The Anatomical Record·S A GarfieldR R Cardell
Feb 1, 1990·Journal of Electron Microscopy Technique·R R Cardell, E L Cardell
May 1, 1977·The Histochemical Journal·L A Lindberg, A Palkama
Jul 18, 2001·Pathology Oncology Research : POR·G Bánhegyi, J Mándl
Feb 1, 1995·The International Journal of Biochemistry & Cell Biology·M al-Habori
Apr 1, 1981·The American Journal of Anatomy·E W ThompsonR L Drake
Jun 1, 1984·The American Journal of Anatomy·S A GarfieldR R Cardell
Dec 1, 1989·Liver·A ChamlianJ M Gulian
Aug 26, 1998·The Journal of Veterinary Medical Science·Y G Yang, T Makita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.