PMID: 374988Jan 11, 1979Paper

Fine structure of the 21S ribosomal RNA region on yeast mitochondrial DNA. II. The organization of sequences in petite mitochondrial DNAs carrying genetic markers from the 21S region

Molecular & General Genetics : MGG
C HeytingP Borst

Abstract

We have investigated the organization of sequences in ten rho- petite mtDNAs by restriction enzyme analysis and electron microscopy. From the comparison of the physical maps of the petite mtDNAs with the physical map of the mtDNA of the parental rho+ strain we conclude that there are at least three different classes of petite mtDNAs: I. Head-to-tail repeats of an (almost) continuous segment of the rho+ mtDNA. II. Head-to-tail repeats of an (almost) continuous segment of the rho+ mtDNA with a terminal inverted duplication. III. Mixed repeats of an (almost) continuous rho+ mtDNA segment. In out petite mtDNAs of the second type, the inverted duplications do not cover the entire conserved rho+ mtDNA segment. We have found that the petite mtDNAs of the third type contain a local inverted duplication at the site where repeating units can insert in two orientations. At least in one case this local inverted duplication must have arisen by mutation. The rearrangements that we have found in the petite mtDNAs do not cluster at specific sites on the rho+ mtDNA map. Large rearrangements or deletions within the conserved rho+ mtDNA segment seem to contribute to the suppressiveness of a petite strain. There is also a positive correlation betw...Continue Reading

References

Apr 29, 1977·Molecular & General Genetics : MGG·M Bolotin-FukuharaH Fukuhara
Apr 23, 1976·Molecular & General Genetics : MGG·H Fukuhara, M Bolotin-Fukuhara
Sep 9, 1977·Molecular & General Genetics : MGG·D Stüber, H Bujard
Aug 16, 1972·Biochimica Et Biophysica Acta·C P HollenbergA C Arnberg
Jan 1, 1972·Annual Review of Biochemistry·P Borst
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Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J LockerG S Getz
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