Fine trabecularized carbon: ideal material and texture for percutaneous device system of permanent left ventricular assist device

Artificial Organs
O TagusariR L Kormos

Abstract

The development of a percutaneous artificial internal organ system requires a reliable biocompatible connection between the external environment and the inside of the human body. Such is necessary for the success of a permanent left ventricular assist device. However, the search for a satisfactory interface at the epidermal level has proven to be difficult. Carbon has been proposed for this application, but its texture does not typically promote ingrowth from surrounding tissue. We have therefore employed a new processing method to produce a fine trabecularized carbon implant. The method for preparing the implant involves infiltrating low temperature pyrolytic carbon into the surface of a carbon core which is wrapped with carbon fabric. This results in a tightly woven porous structure of carbon (carbon fiber diameter: 35-50 microm, maximal pore size >200 microm) with gradually increasing porosity from 15-75%. We implanted test samples percutaneously in a calf for in vivo histological evaluation. Thirty days after implantation epidermal downgrowth was minimal. Microscopic analysis revealed that a thin fibrous capsule surrounded the implant, and mature connective tissue with accompanying blood vessels filled the pores of the fine...Continue Reading

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Citations

Jan 18, 2008·Journal of Biomedical Materials Research. Part a·H E KoschwanezW M Reichert
Aug 10, 2010·Journal of Biomedical Materials Research. Part a·Y FukanoP Fleckman
May 8, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Takayuki AritaKazuo Takakuda
Jun 7, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eleonore C L BolleTim R Dargaville
Sep 23, 2000·Perfusion·A K MahmoodS Westaby

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