Fine-tuned growth phase control of dps, encoding a DNA protection protein, by FIS and H-NS

Molecular Microbiology
K Schnetz

Abstract

Dps, a ferritin-like DNA-binding protein, protects bacterial DNA against oxidative stress and hyper-compacts the nucleoid into a crystalline-like structure. In Escherichia coli, transcription of dps from a single promoter is directed by sigma S-RNA polymerase in stationary phase and by sigma 70-RNA polymerase in fast-dividing cells exposed to oxidative stress. In this issue of Molecular Microbiology, Grainger and co-workers demonstrate that the nucleoid-associated proteins, FIS and H-NS, control sigma factor selection at the dps promoter by a novel mechanism. The finding suggests a simple mechanism of growth phase control of Dps production and has implications for the response to oxidative stress by pathogenic enterobacteria.

References

Jul 14, 1999·Nature·S G WolfA Minsky
Mar 30, 2001·Biochimie·A TraversG Muskhelishvili
Jun 19, 2004·Journal of Bacteriology·Sudha Nair, Steven E Finkel
Sep 12, 2006·Nucleic Acids Research·David C GraingerStephen J W Busby
Nov 10, 2006·The EMBO Journal·Ryosuke L OhniwaKunio Takeyasu
Dec 28, 2006·Nature Reviews. Microbiology·Charles J Dorman
Feb 17, 2007·Molecular Microbiology·Athanasios TypasRegine Hengge
Apr 17, 2007·Nature Structural & Molecular Biology·Emeline BouffartiguesSylvie Rimsky
Jan 8, 2008·Journal of Molecular Biology·Yongping ShaoRobert Osuna
May 3, 2008·Molecular Microbiology·David C GraingerStephen J W Busby

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Citations

Jul 14, 2012·The Biochemical Journal·Kornelius Zeth
Mar 20, 2010·FEMS Microbiology Reviews·Juana María Navarro LlorensEsteban Martínez-García
Aug 1, 2009·EcoSal Plus·Akira Ishihama

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